Creating the bioartificial myocardium for cardiac repair: challenges and clinical targets

被引:22
作者
Chachques, Juan C. [1 ,5 ]
Pradas, Manuel Monleon [2 ]
Bayes-Genis, Antoni [3 ]
Semino, Carlos [4 ]
机构
[1] Univ Paris 05, Pompidou Hosp, Cardiovasc Surg Dept, 56 Rue Leblanc, F-75015 Paris, France
[2] Univ Politecn Valencia, Ctr Biomat & Tissue Engn, Valencia, Spain
[3] Hosp Germans TriasPujol, IGTP, Dept Cardiol, Badalona, Spain
[4] IQS Univ Ramon Llull, Dept Bioengn, Barcelona, Spain
[5] Univ Paris 05, Pompidou Hosp, Lab Biosurg Res, F-75015 Paris, France
关键词
bioartificial myocardium; biohybrid scaffolds; bionanomaterials; cardiac bioregeneration; cardiomyoplasty; cell transplantation; heart failure; myocardial infarction; myocardial regeneration; tissue engineering;
D O I
10.1586/14779072.2013.854165
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The association of stem cells with tissue-engineered scaffolds constitutes an attractive approach for the repair of myocardial tissue with positive effects to avoid ventricular chamber dilatation, which changes from a natural elliptical to spherical shape in heart failure patients. Biohybrid scaffolds using nanomaterials combined with stem cells emerge as new therapeutic tool for the creation of 'bioartificial myocardium' and 'cardiac wrap bioprostheses' for myocardial regeneration and ventricular support. Biohybrids are created introducing stem cells and self-assembling peptide nanofibers inside a porous elastomeric membrane, forming cell niches. Our studies lead to the creation of semi-degradable 'ventricular support bioprostheses' for adaptative LV and/or RV wrapping, designed with the concept of 'helical myocardial bands'. The goal is to restore LV elliptical shape, and contribute to systolic contraction and diastolic filling (suction mechanism). Cardiac wrapping with ventricular bioprostheses may reduce the risk of heart failure progression and the indication for heart transplantation.
引用
收藏
页码:1701 / 1711
页数:11
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