DNA-BINDING COMPOUNDS .3. SYNTHESIS OF A PEPTIDE-LINKED BINUCLEAR PLATINUM(II)-TERPYRIDINE COMPLEX

被引：5

作者：

BRAY, AM

KELLY, DP

MACK, POL

MARTIN, RF

WAKELIN, LPG

机构：

[1] UNIV MELBOURNE,DEPT ORGAN CHEM,PARKVILLE,VIC 3052,AUSTRALIA

[2] PETER MACCALLUM CANC INST,MOLEC SCI GRP,MELBOURNE,VIC 3000,AUSTRALIA

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 03期

关键词：

D O I：

10.1071/CH9900629

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A procedure has been developed for linking two terpyridineplatinum(II), Pt(tpy), chromophores by an oligopeptide chain. It relies on the use of a new reagent, succinimido 3- (triphenylmethylthio)propanoate (2), to acylate the amino end groups of an α.w-diaminoalkane peptide. Subsequent deprotection of the sulfhydryl groups and coupling with [(tpy)PtIICl] Cl yields the binuclear complexes in good yields. This procedure allowed the synthesis of [(tpy)PtS(CH2)2CO-Gly-Gly-Gly-NH(CH2)3NHCO-(CH2)2SPt(tpy)]Cl2 (5b). © 1990 ASEG.

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页码：629 / 634

页数：6

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