EFFECTS OF LOW-DOSES OF ALCOHOL ON DELTA-9-TETRAHYDROCANNABINOLS EFFECTS IN PREGNANT RATS

被引：11

作者：

ABEL, EL ^{[1
]}

SUBRAMANIAN, MG ^{[1
]}

机构：

[1] WAYNE STATE UNIV,CS MOTT CTR HUMAN GROWTH & DEV,DEPT OBSTET & GYNECOL,DETROIT,MI 48201

来源：

LIFE SCIENCES | 1990年 / 47卷 / 18期

关键词：

D O I：

10.1016/0024-3205(90)90374-Z

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pregnant rats were intubated with 50 mg.kg of delta-9-tetrahydrocannabinol (THC) or with THC plus alcohol to determine if a low dose of alcohol (1 g/kg) would significantly increase blood levels of THC. On the basis of this study, a second study was conducted in which pregnant rats were intubated with THC (50, 25 or 0 mg/kg) plus alcohol (2, 1 or 0 g/kg) from gestation day six to parturition. THC reduced birth weights but did not significantly affect litter size or passive avoidance learning. Alcohol did not have a significant effect on offspring birth weight nor did it interact with THC to affect offspring. © 1990.

引用

页码：1677 / 1682

页数：6

共 18 条

[1]

Abel E L, 1987, Reprod Toxicol, V1, P37, DOI 10.1016/0890-6238(87)90069-4

[2]

ABEL EL, 1978, J PHARMACOL EXP THER, V207, P916

[3] ALCOHOL ENHANCEMENT OF MARIJUANA-INDUCED FETOTOXICITY [J].

ABEL, EL .

TERATOLOGY, 1985, 31 (01) :35-40

[4] PRENATAL EXPOSURE TO CANNABIS - A CRITICAL-REVIEW OF EFFECTS ON GROWTH, DEVELOPMENT, AND BEHAVIOR [J].

ABEL, EL .

BEHAVIORAL AND NEURAL BIOLOGY, 1980, 29 (02) :137-156

[5] EFFECTS OF DELTA-9-TETRAHYDROCANNABINOL, PHENOBARBITAL, AND THEIR COMBINATION ON PREGNANCY AND OFFSPRING IN RATS [J].

ABEL, EL ;

TAN, SE ;

SUBRAMANIAN, M .

TERATOLOGY, 1987, 36 (02) :193-198

[6] EFFECTS OF ETHANOL ON PREGNANT RATS AND THEIR OFFSPRING [J].

ABEL, EL .

PSYCHOPHARMACOLOGY, 1978, 57 (01) :5-11

[7] INUTERO ALCOHOL EXPOSURE AND DEVELOPMENTAL DELAY OF RESPONSE-INHIBITION [J].

ABEL, EL .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1982, 6 (03) :369-376

[8]

ABEL EL, J STUD ALCOHOL, V47, P440

[9]

BLACKARD C, 1984, NEW ENGL J MED, V2, P311

[10] DELTA-9-TETRAHYDROCANNABINOL DURING PREGNANCY IN THE RAT .2. EFFECTS ON ONTOGENY OF LOCOMOTOR-ACTIVITY AND NIPPLE ATTACHMENT IN THE OFFSPRING [J].

BRAKE, SC ;

HUTCHINGS, DE ;

MORGAN, B ;

LASALLE, E ;

SHI, T .

NEUROTOXICOLOGY AND TERATOLOGY, 1987, 9 (01) :45-49

← 1 2 →