REPRODUCIBLE WITHDRAWAL CONTRACTIONS OF ISOLATED GUINEA-PIG ILEUM AFTER BRIEF MORPHINE EXPOSURE - EFFECTS OF CLONIDINE AND NIFEDIPINE

被引：42

作者：

VALERI, P

MARTINELLI, B

MORRONE, LA

SEVERINI, C

机构：

[1] Institute of Pharmacology and Pharmacognosy, University of Rome “La Sapienza”, Rome

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 02期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb05364.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Guinea‐pig ileum stored for 30 min in Krebs solution and then mounted in Tyrode solution gave reproducible contracture responses to naloxone after brief exposure to morphine. The preparation lasted for several hours and a variety of pharmacological tests could be made. Clonidine, an α2‐adrenoceptor agonist, and nifedipine, a calcium channel antagonist, both known to interfere with tolerance and physical dependence, inhibited naloxone withdrawal contractures in a dose related way. Their action seemed to be receptor‐mediated since yohimbine and Bay k 8644, respectively, reversed their inhibitory effect. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：115 / 120

页数：6

共 47 条

[1] EFFECTS OF PERIPHERAL AND CENTRAL ADMINISTRATION OF CALCIUM-CHANNEL BLOCKERS IN THE NALOXONE-PRECIPITATED ABSTINENCE SYNDROME IN MORPHINE-DEPENDENT RATS [J].