GASTROINTESTINAL SYMPTOMS IN PARKINSONS-DISEASE

被引：280

作者：

EDWARDS, LL ^{[1
]}

PFEIFFER, RF ^{[1
]}

QUIGLEY, EMM ^{[1
]}

HOFMAN, R ^{[1
]}

BALLUFF, M ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,NEUROL SECT,600 S 42ND ST,OMAHA,NE 68198

来源：

MOVEMENT DISORDERS | 1991年 / 6卷 / 02期

关键词：

Gastrointestinal dysfunction; Parkinson's disease;

D O I：

10.1002/mds.870060211

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We have investigated the prevalence of gastrointestinal (GI) symptoms in 98 individuals with Parkinson's disease (PD) and in a control group of 50. Seventy-nine of those with PD were being treated with dopaminergic medications and 19 were untreated. Those symptoms occurring more frequently in PD patients than in controls included abnormal salivation, dysphagia, nausea, constipation, and defecatory dysfunction. Except for defecatory dysfunction, symptoms did not correlate with treatment but instead correlated with disease severity. This suggests that the GI symptoms of PD reflect direct involvement in the GI tract by the primary disease process.

引用

页码：151 / 156

页数：6

共 24 条

[1] Penner A, Druckerman LJ., Segmental spasms of the esophagus and their relation to parkinsonism, Am J Digest Dis, 9, pp. 282-286, (1942)
[2] Lewitan A, Nathanson L, Slade WR., Megacolon and dilatation of the small bowel in parkinsonism, Gastroenterology, 17, pp. 367-374, (1952)
[3] Lieberman AN, Horowitz L, Redmond P, Dachter L, Lieberman I, Leibowit M., Dysphagia in Parkinson's disease, Am J Gastroenterol, 74, pp. 157-160, (1980)
[4] Bramble MG, Cunliffe J, Dellipiani AW., Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease, J Neurol Neurosurg Psychiatry, 41, pp. 709-712, (1978)
[5] Bushmann M, Dobmeyer S, Leeker L, Perlmutter J., Swallowing abnormalities and their response to treatment in Parkinson's disease, Neurology, 39, pp. 1309-1314, (1989)
[6] Qualman SJ, Haupt HM, Yang P, Hamilton SR., Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease, Gastroenterology, 87, pp. 848-856, (1984)
[7] Tanner CM, Goetz CG, Klawans HL., Autonomic nervous system disorders, Handbook of Parkinson's disease, pp. 152-159, (1987)
[8] Mathers SE, Kempster PA, Law PJ, Et al., Anal sphincter dysfunction in Parkinson's disease, Arch Neurol, 46, pp. 1061-1064, (1989)
[9] Kupsky WJ, Grimes MM, Sweeting J, Et al., Parkinson's disease and megacolon: concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells, Neurology, 37, pp. 1253-1255, (1987)
[10] Eadie MJ, Tyrer JH., Alimentary disorder in parkinsonism, Aust Ann Med, 14, pp. 13-22, (1965)

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