AN APPROACH TO THE CYCLOHEXYL MOIETY OF THE IMMUNOSUPPRESSIVE AGENT FK-506

被引：13

作者：

PEARSON, AJ

RODEN, BA

机构：

[1] Department of Chemistry, Case Western Reserve University, Cleveland

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1990年 / 03期

关键词：

D O I：

10.1039/p19900000723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tricarbonyl(3-methoxycyclohexadienyl)iron hexafluorophosphate, which is readily prepared from 1, 3-dimethoxybenzene, was treated with the enolate of methyl phenylsulphonylacetate to give an adduct which was decarboxylated and decomplexed to give 5-phenylsulphonylmethylcyclohexenone. This compound was converted by a four-step, highly stereoselective, sequence to the trisubstituted cyclohexane (2), which represents a cyclohexyl moiety building block for FK-506.

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页码：723 / 725

页数：3

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