THE IMPORTANCE OF NUCLEUS-ACCUMBENS IN NICOTINE-INDUCED LOCOMOTOR-ACTIVITY

被引：8

作者：

FUNG, YK

机构：

[1] University of Nebraska Medical Center, College of Dentistry, Department of Oral Biology, Lincoln, Nebraska, 68583-0740

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1990年 / 42卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1990.tb07069.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Abstract— Bilateral injections of either nicotine (200 μg) or cytisine (30 or 60 μg) into the nucleus accumbens elicited locomotor hyperactivity in rats. Pretreatment with mecamylamine (2 mg kg−1, s.c.) was effective in attenuating the stimulatory effect of either nicotine or cytisine. This study suggests that nicotinic agonists such as nicotine and cytisine produce their locomotor excitatory effects through stimulation of the mesolimbic dopaminergic pathway. 1990 Royal Pharmaceutical Society of Great Britain

引用

页码：595 / 596

页数：2

共 16 条

[1] THE EFFECTS OF NICOTINE ON BRAIN NEUROTRANSMITTER SYSTEMS [J].

BALFOUR, DJK .

PHARMACOLOGY & THERAPEUTICS, 1982, 16 (02) :269-282

[2]

CLARKE PBS, 1988, J PHARMACOL EXP THER, V246, P701

[3] THE EFFECTS OF NICOTINE ON LOCOMOTOR-ACTIVITY IN NON-TOLERANT AND TOLERANT RATS [J].

CLARKE, PBS ;

KUMAR, R .

BRITISH JOURNAL OF PHARMACOLOGY, 1983, 78 (02) :329-337

[4] AUTORADIOGRAPHIC EVIDENCE FOR NICOTINE RECEPTORS ON NIGROSTRIATAL AND MESOLIMBIC DOPAMINERGIC-NEURONS [J].

CLARKE, PBS ;

PERT, A .

BRAIN RESEARCH, 1985, 348 (02) :355-358

[5] ACUTE EFFECT OF NICOTINE ON THE STRIATAL DOPAMINERGIC SYSTEM IN THE RAT [J].

FUNG, YK ;

LAU, YS .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1986, 38 (12) :920-922

[6] REGULATION OF DOPAMINE RELEASE BY PRESYNAPTIC NICOTINIC RECEPTORS IN RAT STRIATAL SLICES - EFFECT OF NICOTINE IN A LOW CONCENTRATION [J].

GIORGUIEFFCHESSELET, MF ;

KEMEL, ML ;

WANDSCHEER, D ;

GLOWINSKI, J .

LIFE SCIENCES, 1979, 25 (14) :1257-1262

[7] SELECTIVE STIMULATION OF LIMBIC DOPAMINE ACTIVITY BY NICOTINE [J].

GRENHOFF, J ;

SVENSSON, TH .

ACTA PHYSIOLOGICA SCANDINAVICA, 1988, 133 (04) :595-596

[8] FUNCTIONAL EFFECT OF DOPAMINE IN NUCLEUS ACCUMBENS AND IN SOME OTHER DOPAMINE-RICH PARTS OF RAT-BRAIN [J].

JACKSON, DM ;

ANDEN, NE ;

DAHLSTROM, A .

PSYCHOPHARMACOLOGIA, 1975, 45 (02) :139-149

[9]

JEROME A, 1987, PSYCHOPHARMACOLOGY, V93, P397

[10] DOPAMINE MICROINJECTION INTO THE NUCLEUS ACCUMBENS - CORRELATION BETWEEN METABOLISM AND BEHAVIOR [J].

KALIVAS, PW ;

MILLER, JS .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (02) :284-286

← 1 2 →