ESCAPE FROM INHIBITION OF SYNAPTIC TRANSMISSION DURING INVITRO HYPOXIA AND HYPOGLYCEMIA IN THE HIPPOCAMPUS

被引：21

作者：

FOWLER, JC

机构：

[1] Department of Physiology, Texas Tech University Health Sciences Center, School of Medicine, Lubbock

来源：

BRAIN RESEARCH | 1992年 / 573卷 / 01期

关键词：

INVITRO ISCHEMIA; HIPPOCAMPUS; ADENOSINE; BACLOFEN;

D O I：

10.1016/0006-8993(92)90128-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electrophysiological recordings were made from rat hippocampal slices exposed to in vitro ischemic conditions in which the superfused medium is hypoxic and lacking glucose. Under these conditions, the evoked population spike recorded in CA1 is initially depressed and then transiently returns prior to an anoxic depolarization. This transient return in synaptic function under ischemic-like conditions also occurs if the population spike is inhibited by pretreatment with adenosinergic agonists or with the gamma-aminobutyric acid (GABA)B agonist, baclofen.

引用

收藏

页码：169 / 173

页数：5

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