DECREASED LEVELS OF MYELOID PROGENITOR CELLS ASSOCIATED WITH LONG-TERM ADMINISTRATION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS WITH AUTOIMMUNE NEUTROPENIA

被引:9
作者
TANIGUCHI, S [1 ]
SHIBUYA, T [1 ]
HARADA, M [1 ]
NIHO, Y [1 ]
机构
[1] KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1,FUKUOKA,JAPAN
关键词
D O I
10.1111/j.1365-2141.1993.tb04660.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We studied the long-term in vivo effect of recombinant human granulocyte colony stimulating factor (rhG-CSF) on in vitro growth of granulocyte/macrophage colony forming cells (GM-CFC) in bone marrow and peripheral blood obtained from two patients with autoimmune neutropenia, who received rhG-CSF. Along with rhG-CSF treatment for more than 40 d, numbers of GM-CFC-derived colonies from both bone marrow and peripheral blood gradually decreased to a significant level though white blood cells in peripheral blood and nucleated cells in bone marow were increased in number. This observation suggests that long-term administration of rhG-CSF may preferentially activate a differentiation pathway for granulopoiesis while proliferation of GM-CFC is not induced as expected in response to rhG-CSF.
引用
收藏
页码:384 / 387
页数:4
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