THE HEMATOLOGICAL MANIFESTATIONS OF VISCERAL LEISHMANIASIS IN INFANCY AND CHILDHOOD

被引：32

作者：

ALJURAYYAN, NAM ^{[1
]}

ALNASSER, MN ^{[1
]}

ALFAWAZ, IM ^{[1
]}

ALAYED, IH ^{[1
]}

ALHERBISH, AS ^{[1
]}

ALMAZROU, AM ^{[1
]}

ALSOHAIBANI, MO ^{[1
]}

机构：

[1] KING SAUD UNIV, COLL MED, DEPT PATHOL, RIYADH 11461, SAUDI ARABIA

来源：

JOURNAL OF TROPICAL PEDIATRICS | 1995年 / 41卷 / 03期

关键词：

D O I：

10.1093/tropej/41.3.143

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

The haematological manifestations were reviewed in 94 patients (55 males and 39 females) with visceral leishmaniasis. Their ages ranged from 4 months to 12 years (mean per cent 1.8 years). All patients had splenomegaly and were anaemic, while (73 per cent) were neutropenic and (56 per cent) thrombocytopenic. Coagulation abnormalities were encountered in 10 (11 per cent) patients; in four patients this was associated with disseminated intravascular coagulopathy. Bone marrow was hypercellular in (90 per cent), normocellular in (5 per cent), and hypocellular in (4 per cent). Also variable degrees of erythrophagocytosis and leukophagocytosis were noted with preponderance of histiocytes (46 per cent) and granulomatous formation (25 per cent). Low haemosiderin content in the bone marrow was noted, which together with the finding of high serum ferritin is consistent with anaemia of chronic inflammation. Hypersplenism, haemophagocytosis and granulomatous lesions of the bone marrow, chronic inflammation, and dietary factors appear to be the most important factors in the causation of the haematological changes in visceral leishmaniasis.

引用

页码：143 / 148

页数：6

共 25 条

[1]

The leishmaniasis. Report of WHO ExpertCommittee, Tech Rep Ser. WHO No, 701, 10, pp. 23-61, (1984)

[2]

Peters W., Al-Zahrani M.A., The leishmaniasis a publichealth problem in Saudi Arabia, Saudi Med J, 8, pp. 333-343, (1987)

[3]

Al-Zahrani M.A., Peters W., Evans D.A., Smith V., Chin C., Leishmania infecting man and wild animals in SaudiaArabia. 5-Diversity of parasites causing visceral leishmaniasis in man and dogs in the south-west, Trans Roy SocTrop Med Hyg, 83, pp. 503-510, (1989)

[4]

Patil S.B., Rodriques O.P., Visceral leishmaniasis inchildren, Saudi Med J, 11, pp. 99-104, (1990)

[5]

Al Jurayyan N., A1 Ayed I.H., A1 Nasser M., Mugeiren M., Boohene A.G., AI Herbish AS. Visceralleishmaniasis in infancy and childhood, Epidemiologyand clinicopathological study of 63 cases in Al-BahaProvince, Saudi Arabia, J Trop Pediat, 38, pp. 12-16, (1992)

[6]

Cole A.C.E., Kala Azar in East Africa, Trans Roy Soc Trop Med Hyg, 37, pp. 409-420, (1944)

[7]

Chatterryea T., Sen Gupta P.C., Haematological aspectsof Indian Kala-Azar, J Ind Med Ass, 54, pp. 541-552, (1970)

[8]

Woodruff A.W., Topley E., Knight R., Downie C.G.B., Theanaemia of Kala Azar, Br J Haematol, 22, pp. 319-329, (1972)

[9]

Hashemi-Nasab A., Zadeh-Shirazi H., Visceral leishmaniasis (Kala-Azar) in Fars Province, Iran: Study of 130 cases, J Trop Med Hyg, 83, pp. 119-122, (1980)

[10]

Li Volti S., Fischer A., Musumeci S., Hematological andSerological aspects of Mediterranean Kala-Azar ininfancy and childhood, Acta Tropica, 37, pp. 351-365, (1980)

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