FRENCH MULTICENTER EXPERIENCE OF IMPLANTABLE INSULIN PUMPS

被引：87

作者：

BROUSSOLLE, C

JEANDIDIER, N

HANAIREBROUTIN, H

机构：

[1] HOP LYON SUD, LYON, FRANCE

[2] HOP CENT STRASBOURG, STRASBOURG, FRANCE

[3] HOP RANGUELL, TOULOUSE, FRANCE

来源：

LANCET | 1994年 / 343卷 / 8896期

关键词：

D O I：

10.1016/S0140-6736(94)91462-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Limitations of intensive diabetes treatment with subcutaneous insulin include achievement of only near-normoglycaemia and increased risk of hypoglycaemia. Programmable implantable pumps permit variable rates of intraperitoneal insulin infusion. The French experience represents 224 type I adult diabetic patients followed up for 353 patient-years in seven centres, Compared with pre-implantation values with intensive subcutaneous insulin, glycaemic control was significantly improved with implantable pumps: glycosylated haemoglobin fell from 7.4 (1.8)% to 6.8 (1.0)% at 6 months (mean, SD, p < 0.001). The incidence of severe episodes of hypoglycaemia decreased from 15.2 to 2.5 per 100 patient-years (p < 0.001). Intraperitoneal insulin delivery with implantable pumps improved the risk-benefit ratio of intensive insulin.

引用

页码：514 / 515

页数：2

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