INDUCTION OF REVERSIBLE PROTEIN-LINKED DNA BREAKS IN HUMAN OSTEOGENIC-SARCOMA CELLS BY NOVEL CYTOCIDAL COLCHICINE DERIVATIVES WHICH INHIBIT DNA TOPOISOMERASE-II INVITRO - ABSENCE OF CROSS-RESISTANCE IN A COLCHICINE-RESISTANT SUB-CLONE

被引：10

作者：

BASTOW, KF

TATEMATSU, H

BORI, ID

FUKUSHIMA, Y

SUN, L

GOZ, B

LEE, KH

机构：

[1] UNIV N CAROLINA,SCH MED,DEPT PHARMACOL,CHAPEL HILL,NC 27599

[2] UNIV N CAROLINA,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80284-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two colchicine derivatives gave dose-dependent cytocidal effects in human osteogenic sarcoma cells. Unlike colchicine, the analogues stimulated formation of intracellular protein-linked DNA breaks, they inhibited DNA topoisomerase II in vitro, and their cytotoxic action was not modulated by the P-glycoprotein drug-efflux pump.

引用

页码：1045 / 1050

页数：6

共 18 条

[1]

BIOACTIVE ALKALOIDS .4. RESULTS OF RECENT INVESTIGATIONS WITH COLCHICINE AND PHYSOSTIGMINE [J].