TOLERANCE FOR OPIATE ANALGESIA - COMPLEX EFFECT OF ANTAGONISTS OF RECEPTORS FOR EXCITATORY AMINO-ACIDS

被引：2

作者：

BESPALOV, AY ^{[1
]}

ZVARTAU, EE ^{[1
]}

DUMPIS, MA ^{[1
]}

PIOTROVSKII, LB ^{[1
]}

机构：

[1] RUSSIAN ACAD MED SCI,INST EXPTL MED,ST PETERSBURG 22,RUSSIA

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 117卷 / 05期

关键词：

ANTAGONISTS OF EAA RECEPTORS; OPIATES; ANALGESIA; TOLERANCE; LEARNING;

D O I：

10.1007/BF02444297

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of excitatory amino acid receptor antagonists on the development of the conditioned reflex component of the tolerance for morphine analgesia is studied. It is demonstrated that the antagonists of NMDA and nonNMDA receptors reduce the development of associated component of the tolerance, while the magnitude of the nonassociative component changes after co-administration of morphine with NMDA receptor antagonists.

引用

页码：491 / 493

页数：3

共 15 条

[1] THE ROLE OF DESCENDING INHIBITION IN MORPHINE-INDUCED ANALGESIA [J].

ADVOKAT, C .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (09) :330-334

[2] EXCITATORY AMINO-ACID RECEPTORS AND SYNAPTIC PLASTICITY [J].

COLLINGRIDGE, GL ;

SINGER, W .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (07) :290-296

[3] CALCIUM-CHANNEL ANTAGONISTS INCREASE MORPHINE-INDUCED ANALGESIA AND ANTAGONIZE MORPHINE-TOLERANCE [J].

CONTRERAS, E ;

TAMAYO, L ;

AMIGO, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 148 (03) :463-466

[4]

DANYSZ W, 1988, NEUROPHARMACOLOGY, V27, P181

[5] THE NMDA RECEPTOR - CENTRAL ROLE IN PAIN INHIBITION IN RAT PERIAQUEDUCTAL GRAY [J].

JACQUET, YF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 154 (03) :271-276

[6] SEX-DIFFERENCES IN THE INHIBITORY EFFECTS OF THE NMDA ANTAGONIST, MK-801, ON MORPHINE AND STRESS-INDUCED ANALGESIA [J].

LIPA, SM ;

KAVALIERS, M .

BRAIN RESEARCH BULLETIN, 1990, 24 (04) :627-630

[7] DELAYED APPLICATION OF MK-801 ATTENUATES DEVELOPMENT OF MORPHINE-TOLERANCE IN RATS [J].

MAREK, P ;

BENELIYAHU, S ;

VACCARINO, AL ;

LIEBESKIND, JC .

BRAIN RESEARCH, 1991, 558 (01) :163-165

[8]

MAREK P, 1991, BRAIN RES, V547, P77

[9] EXCITATORY AMINO-ACID RECEPTORS, 2ND MESSENGERS AND REGULATION OF INTRACELLULAR CA-2+ IN MAMMALIAN NEURONS [J].

MAYER, ML ;

MILLER, RJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (06) :254-260

[10] SPINAL ANTINOCICEPTIVE EFFECTS OF EXCITATORY AMINO-ACID ANTAGONISTS - QUISQUALATE MODULATES THE ACTION OF N-METHYL-D-ASPARTATE [J].

RAIGORODSKY, G ;

URCA, G .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 182 (01) :37-47

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