LIPASE-CATALYZED RESOLUTION OF (+/-)-2-SUBSTITUTED 1-PROPANOL DERIVATIVES POSSESSING AN AROMATIC RING

被引：3

作者：

AKITA, H

NOZAWA, M

UMEZAWA, I

NAGUMO, S

机构：

[1] School of Pharmaceutical Science, Toho University, Chiba, 274, 2-2-1, Miyama, Funabashi

来源：

BIOCATALYSIS | 1994年 / 9卷 / 1-4期

关键词：

LIPASE; IMMOBILIZED LIPASE; ENANTIOSELECTIVE ESTERIFICATION; ENANTIOSELECTIVE HYDROLYSIS; NATURAL PRODUCT SYNTHESIS; OUDEMANSIN-X;

D O I：

10.3109/10242429408992109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

For the purpose of the chiral synthesis of natural products, lipase-catalyzed kinetic resolutions of three types of 2-substituted 1-propanol derivatives (each having an aromatic ring) was investigated. In every case, chiral recognition of the primary alcohol unit took place to provide the corresponding alcohols and the acetates in high optical purity. The (2S,3S)-5-aryl-2-methyl-3-hydroxy-4E-pentenol 5 was formally converted into the antibiotic, (-)-oudemansin X.

引用

页码：79 / 87

页数：9

共 14 条

[1] ENZYMATIC RESOLUTION OF METHYL 2-ALKYL-2-ARYLACETATES [J].