REPEATEDLY POSITIVE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DNA-POLYMERASE CHAIN-REACTION IN HUMAN IMMUNODEFICIENCY VIRUS-EXPOSED SEROREVERTING INFANTS

被引：35

作者：

BAKSHI, SS

TETALI, S

ABRAMS, EJ

PAUL, MO

PAHWA, SG

机构：

[1] CORNELL UNIV,N SHORE UNIV HOSP,COLL MED,DEPT PEDIAT,MANHASSET,NY 11030

[2] COLUMBIA UNIV COLL PHYS & SURG,HARLEM HOSP CTR,DEPT PEDIAT,NEW YORK,NY 10032

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 1995年 / 14卷 / 08期

关键词：

HUMAN IMMUNODEFICIENCY VIRUS 1 DNA POLYMERASE CHAIN REACTION; EARLY DIAGNOSIS; ABORTIVE INFECTION;

D O I：

10.1097/00006454-199508000-00002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three human immunodeficiency virus type 1 (HIV-1)-exposed children who had repeatedly positive DNA polymerase chain reaction (PCR) tests for HIV in greater than or equal to 5 samples before seroreversion to HIV-negative status are reported. The children belong to a cohort of 210 infants who were born to HIV-infected mothers and were tested at intervals of 1 to 3 months by HIV viral culture, PCR, and p24 antigen; only the PCR was positive in greater than or equal to 5 samples in the children reported here. Their clinical features were indistinguishable from other seroreverters. Ah three children had a transient drop in CD4:CD8 ratio to <1.0. The transiently positive DNA PCR in HIV-exposed infants may indicate either that HIV infection was eliminated by a strong host immune response or that infection was caused by an attenuated/defective strain of virus.

引用

页码：658 / 662

页数：5

共 18 条

[1]

Rogers M.F., Ou C.Y., Kilbourne B., Schochetman G., Advances and problems in the diagnosis of human immunodeficiency virus infection in infants, Pediatr Infect Dis J, 10, pp. 523-531, (1991)

[2]

MMWR, 43, 12, pp. 1-10, (1994)

[3]

Borkowsky W., Krasinski K., Paul D., Et al., Human immunodeficiency virus type 1 antigenemia in children, J Pediatr, 115, pp. 940-945, (1989)

[4]

Borkowsky W., Krasinski K., Pollack H., Et al., Early diagnosis of human immunodeficiency infection in children less than 6 months of age: Comparison of polymerase chain reaction, culture and plasma antigen capture techniques, J Iinfect Dis, 166, pp. 616-619, (1992)

[5]

Mother to child transmission of HIV infection, Lancet, 337, pp. 253-260, (1991)

[6]

Bryson Y.J., Pang S., Wei L.S., Dickover R., Diagne A., Chen I., Clearance of HIV infection in a perinatally infected infant, N Engl J Med, 332, pp. 833-838, (1995)

[7]

Castro B.A., Weiss C.D., Wiviott L.D., Levy J.A., Optimal conditions for recovery of human immunodeficiency virus from peripheral blood mononuclear cells, J Clin Microbiol, 26, pp. 2371-2376, (1988)

[8]

Jackson J.B., Coombs R.W., Sannerud K., Rhame F.S., Balfour H.H., Rapid and sensitive viral culture method for human immunodeficiency virus type 1, J Clin Microbiol, 26, pp. 1416-1418, (1988)

[9]

Ou C.Y., Kwok S., Mitchell S.W., Et al., DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells, Science, 239, pp. 295-297, (1988)

[10]

Mathiesen T., Sundquist V.A., Albert J., Et al., Acid hydrolysis of serum samples to increase detection of HIV antigen, J Virol Methods, 22, pp. 143-148, (1988)

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