GENE-THERAPY AND PHARMACOLOGICAL TREATMENT OF INHERITED NEUROLOGICAL DISORDERS

被引：16

作者：

MARTIN, JB

机构：

[1] The Department of Neurology, University of California, San Francisco, CA 94143-0402

来源：

TRENDS IN BIOTECHNOLOGY | 1995年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0167-7799(00)88898-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The identification of mutant genes responsible for inherited neurological disorders gives an opportunity to consider new approaches to their treatment. Although replacement of defective genes in postmitotic neurons is unlikely to be possible in the near future, the identification of gene products, and definitive delineation of the cellular dysfunction and death that result from mutated gene products, may suggest new therapeutic options. This article reviews these advances and considers approaches that may provide hope for alleviation of these disorders.

引用

页码：28 / 35

页数：8

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