ACTIVATION-INDUCED DEATH OF MATURE T-CELLS IN THE REGULATION OF IMMUNE-RESPONSES

被引：230

作者：

RUSSELL, JH

机构：

[1] JH Russell, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 03期

关键词：

D O I：

10.1016/0952-7915(95)80114-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Deletion of self-reactive clones of immature thymocytes by activation-induced death (AID) is thought to be the primary mechanism for the establishment of self-tolerance in the T-cell compartment. Recent evidence suggests that a genetically distinct but analogous process of AID in mature T cells is important in regulating peripheral immune responses. AID of peripheral T cells requires the expression of functional Fas and Fas ligand by the T-cell population. As qualitatively similar signals from the TCR are responsible for both T-cell expansion in inflammation and T-cell elimination by AID, regulating the balance between these opposing functions plays a crucial role in successful responses to pathogens and tumors while minimizing autoimmunity.

引用

页码：382 / 388

页数：7

共 42 条

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