CLINICAL USE OF THE DETERMINATION OF SEROTONIN IN WHOLE-BLOOD

被引：51

作者：

KREMER, HPH ^{[1
]}

GOEKOOP, JG ^{[1
]}

VANKEMPEN, GMJ ^{[1
]}

机构：

[1] PSYCHIAT HOSP ENDEGEEST,OEGSTGEEST,NETHERLANDS

来源：

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 1990年 / 10卷 / 02期

关键词：

D O I：

10.1097/00004714-199004000-00002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whole blood serotonin (5-hydroxytryptamine, 5-HT) was assayed, and factors possibly influencing 5-HT content were investigated in healthy controls. No significant circadian rhythm or effect of dexamethasone or meals was observed. After use of fluvoxamine, a specific 5-HT reuptake inhibitor, the wholeblood 5-HT concentration of patients was strongly reduced. After treatment with tranylcypromine, an unspecific monoamine oxidase inhibitor (MAOI), the 5-HT content was increased. Determination of whole blood 5-HT in patients treated with fluvoxamine presents a measure of drug compliance. Furthermore, the method may have clinical potential for finding an adequate dose when a 5-HT reuptake inhibitor or an MAOI is used. © 1990 by Williams & Wilkins.

引用

页码：83 / 87

页数：5

共 23 条

[1] STEADY-STATE MODEL FOR PLASMA-FREE AND PLATELET SEROTONIN IN MAN [J].