INTERFERON-GAMMA ENHANCES MESSENGER-RNA AND SURFACE EXPRESSION OF CLASS-I ANTIGEN ON HUMAN EXTRAVILLOUS TROPHOBLAST

被引：40

作者：

GRABOWSKA, A ^{[1
]}

CHUMBLEY, G ^{[1
]}

CARTER, N ^{[1
]}

LOKE, YW ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT PATHOL,DIV CELLULAR & GENET PATHOL,TENNIS COURT RD,CAMBRIDGE CB2 1QP,ENGLAND

来源：

PLACENTA | 1990年 / 11卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0143-4004(05)80221-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human trophoblast cells with immunocytochemical characteristics of the extravillous population have been isolated from ist trimester placentae. Treatment of these cells with IFN-γ increases the expression of Class I antigens at both the cell surface and mRNA level. A similar increase in Class I antigens is also found in JEG-3 choriocarcinoma cells after treatment with IFN-γ. The possibility that aberrant production of IFN-γ may upset the fetal-maternal equilibrium in vivo is discussed. © 1990, Baillière Tindall. All rights reserved.

引用

页码：301 / 308

页数：8

共 26 条

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