REGIONAL LOCALIZATION OF THE HEPATOCYTE GROWTH-FACTOR (HGF) GENE TO HUMAN CHROMOSOME-7 BAND Q21.1

被引:40
作者
FUKUYAMA, R
ICHIJOH, Y
MINOSHIMA, S
KITAMURA, N
SHIMIZU, N
机构
[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,35 SHINANOMACHI,SHINJUKU KU,TOKYO 160,JAPAN
[2] KANSAI MED UNIV,INST LIVER RES,MORIGUCHI,OSAKA 570,JAPAN
关键词
D O I
10.1016/0888-7543(91)90149-9
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Hepatocyte growth factor (HGF) is a polypeptide involved in liver regeneration. Its amino acid sequence and gene structure are similar to those of coagulation-related serine proteases. We have used a cDNA clone of HGF and flow-sorted human chromosomes to assign this gene to chromosome 7. Fluorescence in situ hybridization of the HGF genomic clones to human metaphase chromosome spreads showed the localization of this gene to 7q21. Estimation of fluorescent signals relative to arbitrary reference points (ARPs) allowed further localization to 7q21.1. © 1991.
引用
收藏
页码:410 / 415
页数:6
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