CHARACTERIZATION OF THE GENE ENCODING HUMAN PITUITARY-SPECIFIC TRANSCRIPTION FACTOR, PIT-1

被引：38

作者：

OHTA, K

NOBUKUNI, Y

MITSUBUCHI, H

OHTA, T

TOHMA, T

JINNO, Y

ENDO, F

MATSUDA, I

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT PEDIAT,HONJO 1-1-1,KUMAMOTO 860,JAPAN

[2] NAGOYA CITY UNIV,SCH MED,DEPT HUMAN GENET,NAGOYA,AICHI 467,JAPAN

来源：

GENE | 1992年 / 122卷 / 02期

关键词：

NUCLEOTIDE SEQUENCE; RECOMBINANT DNA; MULTIPLE PITUITARY DEFICIENCIES; PCR GENOME WALKING; CHROMOSOME; 3P11;

D O I：

10.1016/0378-1119(92)90234-G

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Pit-1 is a pituitary-specific transcription factor that binds to and transactivates promoters of growth hormone- and prolactin-encoding genes. A chromosomal gene related to human Pit-1 isolated from human gene libraries was over 14 kb long and split into six exons. All of the splice donor and acceptor sites conformed to the GT/AG rule. The gene was mapped to human chromosome region 3p11.

引用

页码：387 / 388

页数：2

共 6 条

[1] AUTOREGULATION OF PIT-1 GENE-EXPRESSION MEDIATED BY 2 CIS-ACTIVE PROMOTER ELEMENTS
CHEN, RP
INGRAHAM, HA
TREACY, MN
ALBERT, VR
WILSON, L
ROSENFELD, MG
[J]. NATURE, 1990, 346 (6284) : 583 - 586
[2] DWARF LOCUS MUTANTS LACKING 3 PITUITARY CELL-TYPES RESULT FROM MUTATIONS IN THE POU-DOMAIN GENE PIT-1
LI, S
CRENSHAW, EB
RAWSON, EJ
SIMMONS, DM
SWANSON, LW
ROSENFELD, MG
[J]. NATURE, 1990, 347 (6293) : 528 - 533
[3] MAPPING OF THE MYC GENE TO BAND 8Q24.12-]Q24.13 BY R-BANDING AND DISTAL TO FRA(8)(Q24.11), FRA8E, BY FLUORESCENCE INSITU HYBRIDIZATION
TAKAHASHI, E
HORI, T
OCONNELL, P
LEPPERT, M
WHITE, R
[J]. CYTOGENETICS AND CELL GENETICS, 1991, 57 (2-3): : 109 - 111
[4] NUCLEOTIDE-SEQUENCE OF THE COMPLEMENTARY-DNA FOR HUMAN PIT-1/GHF-1
TATSUMI, K
NOTOMI, T
AMINO, N
MIYAI, K
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1129 (02) : 231 - 234
[5] CRETINISM WITH COMBINED HORMONE DEFICIENCY CAUSED BY A MUTATION IN THE PIT1 GENE
TATSUMI, K
MIYAI, K
NOTOMI, T
KAIBE, K
AMINO, N
MIZUNO, Y
KOHNO, H
[J]. NATURE GENETICS, 1992, 1 (01) : 56 - 58
[6] GENE

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