INCREASE IN C-ERBA-ALPHA-2 MESSENGER-RNA IN THE PARVOCELLULAR REGION OF THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS FOLLOWING THYROIDECTOMY IN THE ADULT MALE-RAT

被引：6

作者：

KOIBUCHI, N

GIBBS, RB

JONES, KE

YAMAOKA, S

CHIN, WW

PFAFF, DW

SUZUKI, M

机构：

[1] ROCKEFELLER UNIV,NEUROBIOL & BEHAV LAB,NEW YORK,NY 10021

[2] BRIGHAM & WOMENS HOSP,HOWARD HUGHES MED INST,DEPT MED,DIV GENET,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[4] GUNMA UNIV,INST ENDOCRINOL,DEPT PHYSIOL,MAEBASHI,GUNMA 321,JAPAN

来源：

NEUROSCIENCE LETTERS | 1993年 / 164卷 / 1-2期

关键词：

HYPOTHYROIDISM; THYROID-HORMONE RECEPTOR; RAT HYPOTHALAMUS; T-3; T-4; IN SITU HYBRIDIZATION;

D O I：

10.1016/0304-3940(93)90881-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To examine thyroid hormone regulation of c-erbA alpha 2 mRNA expression in the parvo-cellular region of the paraventricular nucleus of the rat hypothalamus (pPVN), quantitative in situ hybridization was performed using H-3-labeled probe complementary to c-erbA alpha 2 mRNA. Thyroidectomy induced a significant increase in the number of silver grains overlying the cytoplasm in the pPVN relative to sham-operated controls. This effect was prevented by daily injection of thyroxine. These results indicate that hypothyroidism induced an increase in cellular c-erbA alpha 2 mRNA level in the pPVN.

引用

收藏

页码：159 / 162

页数：4

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