DOSE DEPENDENT INHIBITION OF REM-SLEEP IN NORMAL VOLUNTEERS BY BIPERIDEN, A MUSCARINIC ANTAGONIST

被引:31
作者
GILLIN, JC [1 ]
SUTTON, L [1 ]
RUIZ, C [1 ]
GOLSHAN, S [1 ]
HIRSCH, S [1 ]
WARMANN, C [1 ]
SHIROMANI, P [1 ]
机构
[1] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093
关键词
D O I
10.1016/0006-3223(91)90169-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We tested the effect of biperiden (2, 4, and 8 mg per os 30 min before bedtime) on the polygraphically recorded sleep of normal volunteers (n = 8). Biperiden is a cholinergic, muscarinic receptor antagonist that may preferentially block the M1 receptor subtype. Compared with placebo, biperiden significantly prolonged rapid eye movement (REM) latency and suppressed REM sleep time and REM percentage in a dose-dependent manner. These REM suppressing effects of biperiden are similar to those previously reported with scopolamine and other nonselective muscarinic receptor antagonists. Because of uncertainties about the pharmacological specificity of biperiden, further studies are needed to determine the mechanism of action and the role of M1 receptors subtypes in the regulation of REM sleep.
引用
收藏
页码:151 / 156
页数:6
相关论文
共 20 条
[1]   BENNETT,AE AWARD PAPER MUSCARINIC RECEPTOR SUBCLASSIFICATION AND G-PROTEINS - SIGNIFICANCE FOR LITHIUM ACTION IN AFFECTIVE-DISORDERS AND FOR THE TREATMENT OF THE EXTRAPYRAMIDAL SIDE-EFFECTS OF NEUROLEPTICS [J].
AVISSAR, S ;
SCHREIBER, G .
BIOLOGICAL PSYCHIATRY, 1989, 26 (02) :113-130
[2]   THE CARBACHOL-INDUCED ENHANCEMENT OF DESYNCHRONIZED SLEEP SIGNS IS DOSE DEPENDENT AND ANTAGONIZED BY CENTRALLY ADMINISTERED ATROPINE [J].
BAGHDOYAN, HA ;
LYDIC, R ;
CALLAWAY, CW ;
HOBSON, JA .
NEUROPSYCHOPHARMACOLOGY, 1989, 2 (01) :67-79
[3]  
BERGER M, 1989, ARCH GEN PSYCHIAT, V46, P421
[4]   PILOCARPINE, AN ORALLY ACTIVE MUSCARINIC CHOLINERGIC AGONIST, INDUCES REM-SLEEP AND REDUCES DELTA-SLEEP IN NORMAL VOLUNTEERS [J].
BERKOWITZ, A ;
SUTTON, L ;
JANOWSKY, DS ;
GILLIN, JC .
PSYCHIATRY RESEARCH, 1990, 33 (02) :113-119
[5]   AFFINITY AND SELECTIVITY OF BIPERIDEN ENANTIOMERS FOR MUSCARINIC RECEPTOR SUBTYPES [J].
ELTZE, M ;
FIGALA, V .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 158 (1-2) :11-19
[6]  
GERBER U, 1989, SLEEP RES, V18, P10
[7]   EEG SLEEP STUDIES IN PURE PRIMARY ALCOHOLISM DURING SUBACUTE WITHDRAWAL - RELATIONSHIPS TO NORMAL CONTROLS, AGE, AND OTHER CLINICAL-VARIABLES [J].
GILLIN, JC ;
SMITH, TL ;
IRWIN, M ;
KRIPKE, DF ;
SCHUCKIT, M .
BIOLOGICAL PSYCHIATRY, 1990, 27 (05) :477-488
[8]   THE EFFECTS OF SCOPOLAMINE ON SLEEP AND MOOD IN DEPRESSED-PATIENTS WITH A HISTORY OF ALCOHOLISM AND A NORMAL COMPARISON GROUP [J].
GILLIN, JC ;
SUTTON, L ;
RUIZ, C ;
DARKO, D ;
GOLSHAN, S ;
RISCH, SC ;
JANOWSKY, D .
BIOLOGICAL PSYCHIATRY, 1991, 30 (02) :157-169
[9]   LIMBIC CHOLINERGIC PATHWAYS INVOLVED IN SLEEP AND EMOTIONAL BEHAVIOR [J].
HERNANDEZPEON, R ;
TIMOIARIA, C ;
CHAVEZIB.G ;
MORGANE, PJ .
EXPERIMENTAL NEUROLOGY, 1963, 8 (02) :93-&
[10]   ENHANCEMENT OF DESYNCHRONIZED SLEEP SIGNS AFTER PONTINE MICROINJECTION OF THE MUSCARINIC AGONIST BETHANECHOL [J].
HOBSON, JA ;
GOLDBERG, M ;
VIVALDI, E ;
RIEW, D .
BRAIN RESEARCH, 1983, 275 (01) :127-136