REACTIVE OXYGEN METABOLITES INHIBIT SPONTANEOUS LYMPHATIC CONTRACTIONS

被引:45
作者
ZAWIEJA, DC [1 ]
GREINER, ST [1 ]
DAVIS, KL [1 ]
HINDS, WM [1 ]
GRANGER, HJ [1 ]
机构
[1] TEXAS A&M UNIV SYST, COLL MED, MICROCIRCULAT RES INST, COLLEGE STN, TX 77843 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1991年 / 260卷 / 06期
关键词
LYMPH FLOW; LYMPH PUMP; INFLAMMATION; EDEMA; OXYGEN RADICALS; SUPEROXIDE ANION; RAT;
D O I
10.1152/ajpheart.1991.260.6.H1935
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The effects of oxygen-derived free radicals on the contractile activity of the mesenteric collecting lymphatics were evaluated in the anesthetized rat. Lymphatic contractions were monitored before, during and after the application of oxyradicals. Contraction frequency (F), stroke volume (SV), ejection fraction (EF), contraction propagation (PC), and lymph pump flow (LPF) were determined from the lymphatic diameter tracings. Oxyradicals were generated using hypoxanthine and xanthine oxidase. Exposure to oxyradicals inhibited the lymphatic pumping mechanism: 1) F fell from 15.5 +/- 0.8 to 0.8 +/- 0.7 beats/min; 2) EF went from 0.44 +/- 0.02 to 0.08 +/- 0.04; 3) PC dropped from 92 +/- 2 to 56 +/- 8%; and 4) LPF fell precipitously from 41.0 +/- 5.2 to 0.7 +/- 0.4 nl/min. The effects of the oxyradicals were attenuated by superoxide dismutase, implicating superoxide anion as one of the predominant causative agents. We conclude that oxyradicals significantly inhibit the lymph pump and that this inhibition could be a factor contributing to the formation of interstitial edema during inflammation
引用
收藏
页码:H1935 / H1943
页数:9
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