IRON-INDUCED OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION - RELEVANCE TO PARKINSON DISEASE

被引：44

作者：

HARTLEY, A

COOPER, JM

SCHAPIRA, AHV

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT NEUROL SCI,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

[2] UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,LONDON,ENGLAND

来源：

BRAIN RESEARCH | 1993年 / 627卷 / 02期

关键词：

PARKINSONS DISEASE; IRON; MITOCHONDRIA; OXIDATIVE STRESS; CULTURED CELL; PC12;

D O I：

10.1016/0006-8993(93)90341-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inactivation of the mitochondrial respiratory chain in response to iron-induced oxidative stress has been studied in cultured cells. Iron loading resulted in malondialdehyde production, decreased levels of glutathione and reduced specific activities of both complexes I and IV of the respiratory chain. These results are discussed with respect to idiopathic Parkinson's disease, which is associated with increased iron levels and a specific decrease in complex I activity in the substantia nigra.

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页码：349 / 353

页数：5

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