BEHAVIORAL-CHANGES PRODUCED IN RATS BY DEVELOPMENTAL EXPOSURE TO FLUMAZENIL, A BENZODIAZEPINE RECEPTOR ANTAGONIST

被引：9

作者：

CAGIANO, R

DESALVIA, MA

GIUSTINO, A

LACOMBA, C

CUOMO, V

机构：

[1] Institute of Pharmacology, University of Bari, Bari, Piazza G. Cesare

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1993年 / 17卷 / 01期

关键词：

BEHAVIOR; DEVELOPMENTAL EXPOSURE; FLUMAZENIL; RAT;

D O I：

10.1016/0278-5846(93)90039-U

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Prolonged administration of a benzodiazepine receptor antagonist, such as flumazenil (given to the mother at a dose of 3 mg/kg s.c. from day 14 to day 20 of gestation), produced subtle behavioral changes in rat pups. 2. Flumazenil treatment decreased the rate of ultrasonic vocalization in 15-day old male pups removed from their nest. 3. No significant changes in the locomotor activity of the flumazenil-treated group with respect to controls was found at the end of the second and fourth postnatal week. 4. These results suggest that late prenatal exposure to flumazenil induces in rat offspring behavioral changes characterized by decreased emotional responsiveness to environmental challenges.

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收藏

页码：151 / 159

页数：9

相关论文

共 12 条

[1]

BIGNAMI G, 1992, IN PRESS PROG NEUROP

[2] BEHAVIORAL-CHANGES IN THE OFFSPRING OF RATS EXPOSED TO DIAZEPAM DURING GESTATION [J].

CAGIANO, R ;

DESALVIA, MA ;

PERSICHELLA, M ;

RENNA, G ;

TATTOLI, M ;

CUOMO, V .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 177 (1-2) :67-74

[3] ULTRASONIC VOCALIZATION IN RAT PUPS - EFFECTS OF EARLY POSTNATAL EXPOSURE TO HALOPERIDOL [J].

CAGIANO, R ;

SALES, GD ;

RENNA, G ;

RACAGNI, G ;

CUOMO, V .

LIFE SCIENCES, 1986, 38 (15) :1417-1423

[4] GABA - AN EXCITATORY TRANSMITTER IN EARLY POSTNATAL LIFE [J].

CHERUBINI, E ;

GAIARSA, JL ;

BENARI, Y .

TRENDS IN NEUROSCIENCES, 1991, 14 (12) :515-519

[5] INFANTILE STIMULATION AND PERINATAL ADMINISTRATION OF RO-15-1788 - ADDITIVE ANXIETY-REDUCING EFFECTS IN RATS [J].

FERNANDEZTERUEL, A ;

ESCORIHUELA, RM ;

JIMENEZ, P ;

TOBENA, A .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 191 (01) :111-114

[6] EFFECTS OF AGENTS WHICH INTERACT WITH CENTRAL BENZODIAZEPINE BINDING-SITES ON STRESS-INDUCED ULTRASOUNDS IN RAT PUPS [J].

GARDNER, CR ;

BUDHRAM, P .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 134 (03) :275-283

[7] INHIBITION OF ULTRASONIC DISTRESS VOCALIZATIONS IN RAT PUPS BY CHLORDIAZEPOXIDE AND DIAZEPAM [J].

GARDNER, CR .

DRUG DEVELOPMENT RESEARCH, 1985, 5 (02) :185-193

[8] RAT PUP ULTRASONIC ISOLATION CALLS - POSSIBLE MEDIATION BY THE BENZODIAZEPINE RECEPTOR COMPLEX [J].

INSEL, TR ;

HILL, JL ;

MAYOR, RB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (05) :1263-1267

[9] ONTOGENETIC AND PHARMACOLOGICAL DISSOCIATION OF VARIOUS COMPONENTS OF LOCOMOTOR-ACTIVITY AND HABITUATION IN THE RAT [J].

LAVIOLA, G ;

RENNA, G ;

BIGNAMI, G ;

CUOMO, V .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1988, 6 (05) :431-438

[10] PRENATAL EXPOSURE TO DIAZEPAM RESULTS IN ENDURING REDUCTIONS IN BRAIN RECEPTORS AND DEEP SLOW-WAVE SLEEP [J].

LIVEZEY, GT ;

RADULOVACKI, M ;

ISAAC, L ;

MARCZYNSKI, TJ .

BRAIN RESEARCH, 1985, 334 (02) :361-365