MOLECULAR-CLONING AND SEQUENCE-ANALYSIS OF RAT BRADYKININ B-2 RECEPTOR GENE

被引：19

作者：

WANG, DZ ^{[1
]}

MA, JX ^{[1
]}

CHAO, L ^{[1
]}

CHAO, J ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT BIOCHEM & MOLEC BIOL,CHARLESTON,SC 29425

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1994年 / 1219卷 / 01期

关键词：

BRADYKININ B-2 RECEPTOR GENE; CLONING; SEQUENCE ANALYSIS; (RAT);

D O I：

10.1016/0167-4781(94)90264-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bradykinin B-2 receptor mediates the effect of kinin. In order to understand the structure and regulation of its expression, we have cloned and sequenced the gene encoding the rat bradykinin B-2 receptor and its 5' flanking region from a rat genomic library. The B-2 receptor gene spans 7.3 kb in length and contains three exons which are separated by two introns. It encodes a peptide of 366 amino acids. The transcription initiation site was mapped by the primer extension assay. A variant TATA box sequence, an IL-6 response element and a cAMP response element were identified in the 5' flanking region of the rat bradykinin B-2 receptor gene.

引用

页码：171 / 174

页数：4

共 11 条

[1]

BATHON JM, 1991, ANNU REV PHARMACOL, V31, P129

[2]

BHOOLA KD, 1992, PHARMACOL REV, V44, P1

[3] RECENT DEVELOPMENTS IN THE UNDERSTANDING OF BRADYKININ RECEPTORS [J].

BURCH, RM ;

KYLE, DJ .

LIFE SCIENCES, 1992, 50 (12) :829-838

[4] BRADYKININ RECEPTOR ANTAGONISTS [J].

BURCH, RM ;

FARMER, SG ;

STERANKA, LR .

MEDICINAL RESEARCH REVIEWS, 1990, 10 (02) :237-269

[5]

FARMER SG, 1992, ANNU REV PHARMACOL, V32, P511

[6] CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF A HUMAN BRADYKININ (BK-2) RECEPTOR [J].

HESS, JF ;

BORKOWSKI, JA ;

YOUNG, GS ;

STRADER, CD ;

RANSOM, RW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (01) :260-268

[7]

MAHAN LC, 1990, MOL PHARMACOL, V37, P785

[8] EXPRESSION CLONING OF A RAT B2-BRADYKININ RECEPTOR [J].

MCEACHERN, AE ;

SHELTON, ER ;

BHAKTA, S ;

OBERNOLTE, R ;

BACH, C ;

ZUPPAN, P ;

FUJISAKI, J ;

ALDRICH, RW ;

JARNAGIN, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7724-7728

[9] ROLE OF THE KININ-KALLIKREIN PATHWAY IN ALLERGIC DISEASES [J].

POLOSA, R .

ALLERGY, 1993, 48 (04) :217-225

[10]

REGOLI D, 1980, PHARMACOL REV, V32, P1

← 1 2 →