MK-801 DECREASES STRIATAL AND CORTICAL GAD65 MESSENGER-RNA LEVELS

被引：19

作者：

LAPRADE, N

SOGHOMONIAN, JJ

机构：

[1] HOP ENFANTS JESUS,CTR RECH NEUROBIOL,QUEBEC CITY,PQ G1J 1Z4,CANADA

[2] HOP ENFANTS JESUS,DEPT ANAT,QUEBEC CITY,PQ G1J 1Z4,CANADA

[3] UNIV LAVAL,QUEBEC CITY,PQ G1J 1Z4,CANADA

来源：

NEUROREPORT | 1995年 / 6卷 / 14期

关键词：

GAD65; GAD67; NMDA RECEPTOR; MK-801; STRIATUM; CEREBRAL CORTEX; IN SITU HYBRIDIZATION;

D O I：

10.1097/00001756-199510020-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LEVELS of mRNAs encoding for the two isoforms of glutamate decarboxylase, GAD67 and GAD65, were in the rat striatum cerebral cortex quantified following single injections NMDA receptor antagonist MK-801. Acute MK-801 induced a dose-dependent decrease in GAD65 mRNA levels in ventral sectors of the dorsal striatum. No statistically significant changes in GAD67 mRNA levels were measured in the same conditions. In the frontal and cingulate cortex, GAD65 but not GAD67 mRNA levels were significantly decreased after a single high dose of MK-801 (0.1 mg kg(-1)). These results suggest that NMDA receptors are involved in the transcriptional regulation of the GABA synthesizing enzyme, GAD65.

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页码：1885 / 1889

页数：5

相关论文

共 25 条

[1] DOPAMINE AND GLUTAMATE AGONISTS STIMULATE NEURON-SPECIFIC EXPRESSION OF FOS-LIKE PROTEIN IN THE STRIATUM [J].

BERRETTA, S ;

ROBERTSON, HA ;

GRAYBIEL, AM .

JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (03) :767-777

[2] PARALLEL DECREASE OF GLUTAMIC-ACID DECARBOXYLASE AND PREPROENKEPHALIN MESSENGER-RNA IN THE RAT STRIATUM FOLLOWING CHRONIC TREATMENT WITH A DOPAMINERGIC D1 ANTAGONIST AND D2 AGONIST [J].

CABOCHE, J ;

VERNIER, P ;

JULIEN, JF ;

ROGARD, M ;

MALLET, J ;

BESSON, MJ .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (02) :428-435

[3] INVIVO PRESYNAPTIC CONTROL OF DOPAMINE RELEASE IN THE CAT CAUDATE-NUCLEUS .2. FACILITATORY OR INHIBITORY INFLUENCE OF L-GLUTAMATE [J].

CHERAMY, A ;

ROMO, R ;

GODEHEU, G ;

BARUCH, P ;

GLOWINSKI, J .

NEUROSCIENCE, 1986, 19 (04) :1081-1090

[4] PRESYNAPTIC REGULATION OF NEUROTRANSMITTER RELEASE IN THE BRAIN - FACTS AND HYPOTHESIS [J].

CHESSELET, MF .

NEUROSCIENCE, 1984, 12 (02) :347-375

[5] L-GLUTAMATE-EVOKED RELEASE OF DOPAMINE FROM SYNAPTOSOMES OF THE RAT STRIATUM - INVOLVEMENT OF AMPA AND N-METHYL-D-ASPARTATE RECEPTORS [J].

DESCE, JM ;

GODEHEU, G ;

GALLI, T ;

ARTAUD, F ;

CHERAMY, A ;

GLOWINSKI, J .

NEUROSCIENCE, 1992, 47 (02) :333-339

[6]

DREJER J, 1987, J NEUROSCI, V7, P2910

[7] 2 GENES ENCODE DISTINCT GLUTAMATE DECARBOXYLASES [J].

ERLANDER, MG ;

TILLAKARATNE, NJK ;

FELDBLUM, S ;

PATEL, N ;

TOBIN, AJ .

NEURON, 1991, 7 (01) :91-100

[8]

ESCLAPEZ M, 1994, NEUROSCIENCE, V14, P1834

[9] DIFFERENT DISTRIBUTIONS OF GAD(65) AND GAD(67) MESSENGER-RNAS SUGGEST THAT THE 2 GLUTAMATE DECARBOXYLASES PLAY DISTINCTIVE FUNCTIONAL ROLES [J].

FELDBLUM, S ;

ERLANDER, MG ;

TOBIN, AJ .

JOURNAL OF NEUROSCIENCE RESEARCH, 1993, 34 (06) :689-706

[10] TYROSINE HYDROXYLASE IMMUNOREACTIVE BOUTONS IN SYNAPTIC CONTACT WITH IDENTIFIED STRIATONIGRAL NEURONS, WITH PARTICULAR REFERENCE TO DENDRITIC SPINES [J].

FREUND, TF ;

POWELL, JF ;

SMITH, AD .

NEUROSCIENCE, 1984, 13 (04) :1189-1215