BROMAZEPAM IN GENERALIZED ANXIETY - RANDOMIZED, MULTIPRACTICE COMPARISONS WITH BOTH CHLORPROTHIXENE AND PLACEBO

被引:12
作者
KRAGHSORENSEN, P
HOLM, P
FYNBOE, C
SCHAUMBURG, E
ANDERSEN, B
BECH, P
PICHARD, J
机构
[1] ROCHE AS,INT CLIN RES,NORD REG,COPENHAGEN,DENMARK
[2] HERLEV UNIV HOSP,DEPT SURG GASTROENTEROL D,HERLEV,DENMARK
[3] HERLEV UNIV HOSP,GEN PRACTICE,HERLEV,NETHERLANDS
[4] GEN HOSP,DEPT PSYCHIAT P,HILLEROD,DENMARK
关键词
Benzodiazepine; General practice; Generalized anxiety; Neuroleptic; Placebo; Randomized trial;
D O I
10.1007/BF02244611
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Bromazepam was compared with placebo and with chlorprothixene in a randomized, double-blind group-comparative multicenter trial in general practice. Two hundred and forty-five patients with generalized anxiety disorder (DSM-III 1980) were treated for 2 weeks with two daily doses of bromazepam, 3 mg or chlorprothixene, 15 mg or placebo. Median reductions in Hamilton Anxiety rating were 12 (bromazepam), 10.3 (chlorprothixene) and 7.3 (placebo). The study revealed significant superiority of bromazepam over placebo (median differences 3.3, 95% confidence limits: 0.3 and 6.1) but not over chlorprothixene (median difference 1.4, 95% confidence limits -0.8 and +3.5). Significantly higher rates of tiredness, sedation and hypersomnia were found on bromazepam and chlorprothixene compared to placebo. Tolerance was rated as "at least good" in 85.6% on bromazepam, in 86% on chlorprothixene and in 87.8% on placebo. Neither previous psychopharmacological treatment nor presence of psychosocial stress were of perceptible influence. Bromazepam and chlorprothixene are both superior to placebo in generalized anxiety states treated in general practice, but spontaneous improvements/placebo effects are substantial. © 1990 Springer-Verlag.
引用
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页码:383 / 386
页数:4
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