LOCALIZED INVIVO H-1 SPECTROSCOPY OF HUMAN SKELETAL-MUSCLE - NORMAL AND PATHOLOGICAL FINDINGS

被引：29

作者：

BONGERS, H

SCHICK, F

SKALEJ, M

JUNG, WI

STEVENS, A

机构：

[1] Department of Neuroradiology, University of Tübingen

[2] Department of Physics, University of Tübingen

[3] Department of Neurology, University of Tübingen

来源：

MAGNETIC RESONANCE IMAGING | 1992年 / 10卷 / 06期

关键词：

INVIVO H-1 NMR SPECTROSCOPY; RELAXATION TIMES; MUSCLE; MYOSITIS; RADIATION;

D O I：

10.1016/0730-725X(92)90450-E

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To obtain high signal to noise ratio in small volume elements (8 cm3), in vivo H-1 NMR spectroscopy of normal and diseased human skeletal muscle was performed using a double spin-echo localization method on a 1.5-T whole body system. High resolved spectra of normal calf muscle show the well known resonances of lipids (methyl, methylene, olefinic, and other fatty acid resonances), creatine/phosphocreatine, choline/carnitine, taurine, and histidine with good intraindividual reproducibility. Pronounced intraindividual differences in the lipid range were found between different upper thigh muscle groups. On pathologic conditions like myopathia, myositis or irradiation damage the spectral lipid content was increased. Three months after local irradiation of the medial vastus muscle (50 Gy), the localized H-1 NMR spectrum showed a complete loss of the choline and creatine signals. In a case of M. Behcet with muscular involvement the relative reduction of the choline signal may provide an insight in the pathobiochemistry. The results of our investigations in nine healthy volunteers and three patients are presented in detail including relaxation times of the metabolites.

引用

页码：957 / 964

页数：8

共 17 条

[1]

Bottomley, Human in vivo NMR spectroscopy in diagnostic medicine: clinical tool or research probe?, Radiology, 170, pp. 1-15, (1989)

[2]

Aue, Localization methods for in vivo NMR spectroscopy, Rev. Magn. Res. Medicine, 1, pp. 21-72, (1986)

[3]

Barany, Venkatasubramanian, Mok, Siegel, Abraham, Wycliffe, Mafee, Quantitative and qualitative fat analysis in human leg muscle of neuromuscular diseases by <sup>1</sup>H MR spectroscopy in vivo, Magn. Reson. Med., 10, pp. 210-226, (1989)

[4]

Bruhn, Frahm, Gyngell, Merboldt, Hanicke, Sauter, Localized proton MR spectroscopy of human muscle in vivo, Book of abstracts, (1989)

[5]

Bruhn, Frahm, Gyngell, Merboldt, Hanicke, Sauter, Localized proton NMR spectroscopy using stimulated echoes: applications to human skeletal muscle in vivo, Magn. Reson. Med., 17, pp. 82-94, (1991)

[6]

Jackson, Narayana, Flamig, One-dimensional spectroscopic imaging with stimulated echoes: phantom and human leg studies, Magn. Reson. Imaging, 8, pp. 153-159, (1990)

[7]

Narayana, Jackson, Hazle, Fotedar, Kulkarni, Flamig, In vivo localized proton spectroscopic studies of human gastrocnemius muscle, Magn. Reson. Med., 8, pp. 151-159, (1988)

[8]

Narayana, Hazle, Jackson, Fotedar, Kulkarni, In vivo <sup>1</sup>H spectroscopic studies of human gastrocnemius muscle at 1.5 T, Magn. Reson. Imaging, 6, pp. 481-485, (1988)

[9]

Frahm, Merboldt, Hanicke, Localized proton spectroscopy using stimulated echoes, J. Magn. Reson., 72, pp. 502-508, (1987)

[10]

Frahm, Bruhn, Gyngell, Merboldt, Hanicke, Sauter, Localized high-resolution proton NMR spectroscopy in different regions of the human brain in vivo: relaxation times and concentrations of cerebral metabolites, Magn. Reson. Med., 9, pp. 79-93, (1989)

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