RESISTANCE OF BETA-ENDORPHIN TO DEXAMETHASONE INHIBITION IN PARKINSONS-DISEASE AND ALZHEIMERS-DISEASE

被引：3

作者：

AIRAGHI, L ^{[1
]}

CATANIA, A ^{[1
]}

GRAMIGNA, C ^{[1
]}

MANFREDI, MG ^{[1
]}

FRANCESCHI, M ^{[1
]}

ZANUSSI, C ^{[1
]}

机构：

[1] UNIV MILAN,NEUROL CLIN 4,I-20122 MILAN,ITALY

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 1991年 / 56卷 / 1-4期

关键词：

BETA-ENDORPHIN; ALZHEIMERS DISEASE; PARKINSONS DISEASE; DEXAMETHASONE SUPPRESSION;

D O I：

10.3109/00207459108985406

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The response of plasma beta-endorphin (beta-EP) to dexamethasone suppression was studied in 14 patients with Alzheimer's disease (AD), 14 patients with Parkinson's disease (PD), and 13 age-matched controls in order to evaluate whether an impairment of the opiate system is present in these neurodegenerative disorders. Basal circulating beta-EP was in normal range in all subjects, although the mean concentration was slightly reduced in the patients compared to controls. After 1 mg dexamethasone given at 11:00p.m. the night before, plasma beta-EP concentration measured at 08:00 a.m. and 04:00 p.m. was not inhibited in AD and PD patients while it was significantly reduced in controls. Circulating ACTH and Cortisol were similar in patients and controls and a normal inhibition of plasma Cortisol after dexamethasone was observed in 13/14 AD and 12/14PD patients. The resistance of beta-EP to dexamethasone inhibition is consistent with previous clinical and experimental data indicating a disorder of the opiate system in brain degenerative diseases. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：73 / 79

页数：7

共 42 条

[1]

AIRAGHI L, 1989, 14TH WORLD C NEUR NE, pC403

[2] DEXAMETHASONE SUPPRESSION TEST AND SERUM PROLACTIN IN DEMENTIA DISORDERS [J].