ATOVAQUONE - A NOVEL BROAD-SPECTRUM ANTIINFECTIVE DRUG

被引：95

作者：

HUDSON, AT

机构：

[1] Research Laboratories, Beckenham, BR3 3BS, Langley Court

来源：

PARASITOLOGY TODAY | 1993年 / 9卷 / 02期

关键词：

D O I：

10.1016/0169-4758(93)90040-M

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Atovaquone is a novel hydroxynaphthoquinone that is currently showing clinical promise for the treatment of malaria and the AIDS-associated diseases Pneumocystis carinii pneumonia and toxoplasmosis. The drug is the end product of half a century of research by numerous groups who have investigated the antiparasitic properties of many related compounds. Atovaquone is the only member of the series to show therapeutic activity in humans when taken orally. In this article, Alan Hudson explores the background to the discovery of this drug and reviews its mode of action, and biological and clinical profiles.

引用

页码：66 / 68

页数：3

共 22 条

[1] INVITRO AND INVIVO ACTIVITIES OF THE HYDROXYNAPHTHOQUINONE 566C80 AGAINST THE CYST FORM OF TOXOPLASMA-GONDII [J].