LIVER-INJURY RELATED TO AMOXICILLIN-CLAVULANIC ACID - INTERLOBULAR BILE-DUCT LESIONS AND EXTRAHEPATIC MANIFESTATIONS

被引：51

作者：

HAUTEKEETE, ML

BRENARD, R

HORSMANS, Y

HENRION, J

VERBIST, L

DERUE, G

DRUEZ, P

OMAR, M

KOCKX, M

HUBENS, H

HABER, I

RAHIER, J

GEUBEL, AP

机构：

[1] HOP ST JOSEPH,GILLY,BELGIUM

[2] CLIN UNIV ST LUC,B-1200 BRUSSELS,BELGIUM

[3] HOP JOLIMONT,HAINE ST PAUL,BELGIUM

[4] JAN PALFIJN HOSP,ANTWERP,BELGIUM

来源：

JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 01期

关键词：

ACUTE INTERSTITIAL NEPHRITIS; ACUTE SIALADENITIS; CHOLESTASIS; LACRIMAL GLAND;

D O I：

10.1016/0168-8278(95)80262-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We report eight cases of liver injury related to amoxycillin-clavulanate, Liver biopsy performed in seven patients revealed varying degrees of injury to interlobular bile ducts in all cases. Lesions included irregularity of the nuclei, vacuolization of the cytoplasm, lymphocytic infiltration, destruction and endothelialization of the bile duct epithelium. Ductopenia was not observed. In two patients liver injury was accompanied by prominent extrahepatic manifestations (acute interstitial nephritis in one and acute lacrimal gland inflammation and sialadenitis with prolonged xerostomia in the other). We conclude that interlobular bile-duct lesions of varying severity are a common feature in liver injury related to amoxycillin-clavulanate, Side effects of the drug include acute interstitial nephritis and sialadenitis.

引用

页码：71 / 77

页数：7

共 34 条

[1]

INTRAHEPATIC CHOLESTASIS INDUCED BY AMOXICILLIN CLAVULANIC ACID (AUGMENTIN) - A REPORT ON 2 CASES [J].