MOLECULAR EPIDEMIOLOGY OF HEPATITIS-C VIRUS-INFECTION AMONG INTRAVENOUS-DRUG-USERS

被引:74
作者
SILINI, E
BONO, F
CIVIDINI, A
CERINO, A
MACCABRUNI, A
TINELLI, C
BRUNO, S
BELLOBUONO, A
MONDELLI, MU
机构
[1] IRCCS,POLICLIN SAN MATTEO,IST CLIN MALATTIE INFETT,DEPT INFECT DIS,I-27100 PAVIA,ITALY
[2] IRCCS,POLICLIN SAN MATTEO,DEPT PATHOL,PAVIA,ITALY
[3] IRCCS,POLICLIN SAN MATTEO,DEPT BIOSTAT,PAVIA,ITALY
[4] UNIV PAVIA,I-27100 PAVIA,ITALY
[5] OSPED SAN PAOLO,DIV INTERNAL MED 3,MILAN,ITALY
[6] OSPED NIGUARDA CA GRANDA,DIV HEPATOL CRESPI,MILAN,ITALY
来源
JOURNAL OF HEPATOLOGY | 1995年 / 22卷 / 06期
关键词
DRUG USERS; EPIDEMIOLOGY; GENOTYPES; HEPATITIS C VIRUS;
D O I
10.1016/0168-8278(95)80225-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: The clinico-pathological features of hepatitis C virus infection in intravenous drug users are different from those found in other hepatitis C virus-infected patients, Our aim was to test whether specific viral variants circulate within this particular patient population. Methods: We studied the distribution of hepatitis C virus genotypes in 90 drug addicts and 484 controls, according to the method described by Okamoto. Results: Hepatitis C virus type la and 3a infections were more frequent among intravenous drug users than in 125 age-matched controls (48.8% and 21.1% vs 17.6% and 11.2%), accounting for the majority of infections in intravenous drug users, Analysis of hepatitis C virus genotypes according to age showed that,in the general population, hepatitis C virus types la and 3a were more prevalent among patients younger than 40 years of age than in older individuals (17.6% and 11.2% vs. 1.4% and 0.6%). Conclusions: These findings suggest that hepatitis C virus types la and 3a were recently introduced in Italy, presumably via needle-sharing among intravenous drug users, and from this reservoir they are extending to the general population, particularly among younger subjects.
引用
收藏
页码:691 / 695
页数:5
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