DIVERGENT HUMAN PAPILLOMAVIRUS TYPE-16 VARIANTS ARE SEROLOGICALLY CROSS-REACTIVE

被引：56

作者：

CHENG, G

ICENOGLE, JP

KIRNBAUER, R

HUBBERT, NL

STLOUIS, ME

HAN, CL

SVARE, EI

KJAER, SK

LOWY, DR

SCHILLER, JT

机构：

[1] NCI,CELLULAR ONCOL LAB,BETHESDA,MD 20892

[2] CTR DIS CONTROL & PREVENT,NATL CTR INFECT DIS,ATLANTA,GA 30341

[3] DANISH CANC SOC,DIV CANC EPIDEMIOL,COPENHAGEN,DENMARK

来源：

JOURNAL OF INFECTIOUS DISEASES | 1995年 / 172卷 / 06期

关键词：

D O I：

10.1093/infdis/172.6.1584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is not known whether DNA sequence variants of human papillomavirus type 16 (HPV-16) are distinct serotypes. To examine this question, the reactivities of women's sera from Zaire (n = 97) and Denmark (n = 123) were compared in IgG-specific ELISAs based on virus-like particles (VLPs) composed of the L1 major capsid protein derived from an HPV-16 variant common in central Africa (Z-1194) or one common in northern Europe (114K), These L1s differ in seven amino acids, There was a strong correlation between reactivity in the two assays for both sets of sera (correlation coefficients, 0.73 and 0.85 for Zairian and Danish sera, respectively), In only 1 serum was there evidence for a specific reaction to one but not the other VLP variant, The results support the conclusion that the virions of strains Z-1194 and 114K are serologically cross-reactive.

引用

页码：1584 / 1587

页数：4

共 16 条

[1]

ANDERSSONELLSTR.A, 1994, LANCET, V344, P1435

[2] PREVALENCE OF HUMAN PAPILLOMAVIRUS IN CERVICAL-CANCER - A WORLDWIDE PERSPECTIVE [J].

BOSCH, FX ;

MANOS, MM ;

MUNOZ, N ;

SHERMAN, M ;

JANSEN, AM ;

PETO, J ;

SCHIFFMAN, MH ;

MORENO, V ;

KURMAN, R ;

SHAH, KV ;

ALIHONOU, E ;

BAYO, S ;

MOKHTAR, HC ;

CHICAREON, S ;

DAUDT, A ;

DELOSRIOS, E ;

GHADIRIAN, P ;

KITINYA, JN ;

KOULIBALY, M ;

NGELANGEL, C ;

TINTORE, LMP ;

RIOSDALENZ, JL ;

SARJADI ;

SCHNEIDER, A ;

TAFUR, L ;

TEYSSIE, AR ;

ROLON, PA ;

TORROELLA, M ;

TAPIA, AV ;

WABINGA, HR ;

ZATONSKI, W ;

SYLLA, B ;

VIZCAINO, P ;

MAGNIN, D ;

KALDOR, J ;

GREER, C ;

WHEELER, C .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (11) :796-802

[3] MOLECULAR VARIANTS OF HUMAN PAPILLOMAVIRUS TYPE-16 FROM 4 CONTINENTS SUGGEST ANCIENT PANDEMIC SPREAD OF THE VIRUS AND ITS COEVOLUTION WITH HUMANKIND [J].

CHAN, SY ;

HO, L ;

ONG, CK ;

CHOW, V ;

DRESCHER, B ;

DURST, M ;

TERMEULEN, J ;

VILLA, L ;

LUANDE, J ;

MGAYA, HN ;

BERNARD, HU .

JOURNAL OF VIROLOGY, 1992, 66 (04) :2057-2066

[4] PHYLOGENETIC ANALYSIS OF 48 PAPILLOMAVIRUS TYPES AND 28 SUBTYPES AND VARIANTS - A SHOWCASE FOR THE MOLECULAR EVOLUTION OF DNA VIRUSES [J].

CHAN, SY ;

BERNARD, HU ;

ONG, CK ;

CHAN, SP ;

HOFMANN, B ;

DELIUS, H .

JOURNAL OF VIROLOGY, 1992, 66 (10) :5714-5725

[5] A PAPILLOMAVIRUS DNA FROM A CERVICAL-CARCINOMA AND ITS PREVALENCE IN CANCER BIOPSY SAMPLES FROM DIFFERENT GEOGRAPHIC REGIONS [J].

DURST, M ;

GISSMANN, L ;

IKENBERG, H ;

ZURHAUSEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12) :3812-3815

[6] THE GENETIC DRIFT OF HUMAN PAPILLOMAVIRUS TYPE-16 IS A MEANS OF RECONSTRUCTING PREHISTORIC VIRAL SPREAD AND THE MOVEMENT OF ANCIENT HUMAN-POPULATIONS [J].

HO, L ;

CHAN, SY ;

BURK, RD ;

DAS, BC ;

FUJINAGA, K ;

ICENOGLE, JP ;

KAHN, T ;

KIVIAT, N ;

LANCASTER, W ;

MAVROMARANAZOS, P ;

LABROPOULOU, V ;

MITRANIROSENBAUM, S ;

NORRILD, B ;

PILLAI, MR ;

STOERKER, J ;

SYRJAENEN, K ;

SYRJAENEN, S ;

TAY, SK ;

VILLA, LL ;

WHEELER, CM ;

WILLIAMSON, AL ;

BERNARD, HU .

JOURNAL OF VIROLOGY, 1993, 67 (11) :6413-6423

[7] GENOTYPES AND SEQUENCE VARIANTS OF HUMAN PAPILLOMAVIRUS DNAS FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED WOMEN WITH CERVICAL INTRAEPITHELIAL NEOPLASIA [J].

ICENOGLE, JP ;

LAGA, M ;

MILLER, D ;

MANOKA, AT ;

TUCKER, RA ;

REEVES, WC .

JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (06) :1210-1216

[8] A VIRUS-LIKE PARTICLE ENZYME-LINKED-IMMUNOSORBENT-ASSAY DETECTS SERUM ANTIBODIES IN A MAJORITY OF WOMEN INFECTED WITH HUMAN PAPILLOMAVIRUS TYPE-16 [J].

KIRNBAUER, R ;

HUBBERT, NL ;

WHEELER, CM ;

BECKER, TM ;

LOWY, DR ;

SCHILLER, JT .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1994, 86 (07) :494-499

[9] PAPILLOMAVIRUS L1 MAJOR CAPSID PROTEIN SELF-ASSEMBLES INTO VIRUS-LIKE PARTICLES THAT ARE HIGHLY IMMUNOGENIC [J].

KIRNBAUER, R ;

BOOY, F ;

CHENG, N ;

LOWY, DR ;

SCHILLER, JT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) :12180-12184

[10]

KIRNBAUER R, 1993, J VIROL, V67, P6923

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