AURIN TRICARBOXYLIC-ACID, THE ANTI-AIDS COMPOUND, PREVENTS THE BINDING OF INTERFERON-ALPHA TO ITS RECEPTOR

被引：19

作者：

GAN, YX ^{[1
]}

WEAVER, JL ^{[1
]}

PINE, PS ^{[1
]}

ZOON, KC ^{[1
]}

ASZALOS, A ^{[1
]}

机构：

[1] US FDA,DIV CYTOKINE BIOL,WASHINGTON,DC 20204

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91590-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Binding of HIV to its receptor, the CD4 molecule of lymphocytes, can be prevented by chemical agents. These agents could be considered as potential anti-AIDS drugs. We have shown that aurin tricarboxylic acid (ATA, 3 μM) specifically blocks the binding of gp120, the HIV coat protein, to the CD4 molecule. We have also found that ATA prevents the binding of interferon-α to its receptor in a dose-dependent manner (12-50 μM range). Membrane potential shift, associated with binding of interferon-α to its receptor, was also blocked by ATA in a dose-dependent fashion. Our results indicate that potential anti-AIDS drugs should be screened for such undesired side effects. © 1990.

引用

页码：1298 / 1303

页数：6

共 19 条

[1]

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[2]

ASZALOS A, 1987, PROG ANTIMICROB ANTI, V3, P720

[3] ALPHA-INTERFERON ACCELERATES LATERAL DIFFUSION OF DAUDI CELL-SURFACE DIFFERENTIATION ANTIGENS - MEASUREMENT BY FLUORESCENCE REDISTRIBUTION AFTER PHOTOBLEACHING [J].