EFFECT OF OTOTOPICAL APPLICATION OF A CORTICOSTEROID PREPARATION ON COCHLEAR FUNCTION

被引：12

作者：

IKEDA, K

MORIZONO, T

机构：

[1] Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, MN

来源：

AMERICAN JOURNAL OF OTOLARYNGOLOGY | 1991年 / 12卷 / 03期

关键词：

CORTICOSTEROID; COCHLEA; ROUND WINDOW MEMBRANE; COMPOUND ACTION POTENTIAL;

D O I：

10.1016/0196-0709(91)90145-6

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The ototoxicity of the corticosteroid triamcinolone diacetate was investigated using the compound action potential (CAP) of the auditory nerve as a parameter when the drug was applied to the middle ear cavity of the chinchilla. Comparison with the contralateral ear, instilled with Ringer's solution, demonstrated no significant difference in the threshold, amplitude, and latency of the CAP responses at the overall frequencies tested. In addition, the side difference of the CAP threshold in individual animals showed that this corticosteroid did not induce cochlear dysfunction in any case. © 1991.

引用

页码：150 / 153

页数：4

共 28 条

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