DOSE-DEPENDENT PHARMACOKINETICS - EXPERIMENTAL-OBSERVATIONS AND THEORETICAL CONSIDERATIONS

被引：69

作者：

LIN, JH

机构：

[1] Merck Research Laboratories, Pennsylvania, 19486, West Point

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1994年 / 15卷 / 01期

关键词：

D O I：

10.1002/bdd.2510150102

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Clinically, absorption and elimination of most drugs follow linear kinetics, and pharmacokinetic parameters describing absorption and elimination of a drug do not change over the therapeutic dose range. However, dose-dependent pharmacokinetics have been reported more frequently in preclinical studies, particularly in toxicity studies, where high doses are often employed. This review highlights the major types of dose-dependent pharmacokinetics with unique examples.

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页码：1 / 31

页数：31

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