INTRACELLULAR-TRANSPORT OF INOSITOL-CONTAINING SPHINGOLIPIDS IN THE YEAST, SACCHAROMYCES-CEREVISIAE

被引：24

作者：

HECHTBERGER, P ^{[1
]}

DAUM, G ^{[1
]}

机构：

[1] GRAZ TECH UNIV, INST BIOCHEM & LEBENSMITTELCHEM, A-8010 GRAZ, AUSTRIA

来源：

FEBS LETTERS | 1995年 / 367卷 / 02期

关键词：

SPHINGOLIPID; LIPID TRANSPORT; PROTEIN SECRETION; PLASMA MEMBRANE; SACCHAROMYCES CEREVISIAE;

D O I：

10.1016/0014-5793(95)00567-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Organelles of the early protein secretion pathway (ER, Golgi) are involved in biosynthesis and intracellular migration of the yeast sphingolipids, inositolphosphorylceramide (IPC), mannosylinositolphosphorylceramide (MIPC), and mannosyl-diinositolphosphorylceramide (M(IP)(2)C). Cycloheximide and nocodazole neither block biosynthesis of sphingolipids, nor ER to Golgi transport of IPC. In contrast, treatment of yeast cells with brefeldin A, which affects integrity of the Golgi, decreases formation of IPC and MIPC. Interruption of late steps of protein secretion (Golgi to plasma membrane transport) in temperature-sensitive secretory mutants prevents sphingolipids from being transported to the cell periphery.

引用

页码：201 / 204

页数：4

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