PURIFICATION AND PROPERTIES OF A CYTOLYTIC TOXIN IN VENOM OF THE JELLYFISH CARYBDEA-MARSUPIALIS

被引：76

作者：

ROTTINI, G ^{[1
]}

GUSMANI, L ^{[1
]}

PAROVEL, E ^{[1
]}

AVIAN, M ^{[1
]}

PATRIARCA, P ^{[1
]}

机构：

[1] UNIV TRIESTE,DEPT BIOL,I-34127 TRIESTE,ITALY

来源：

TOXICON | 1995年 / 33卷 / 03期

关键词：

D O I：

10.1016/0041-0101(94)00174-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A haemolytic toxin was purified by ion-exchange chromatography and FPLC gel filtration from the nematocysts of the jellyfish Carybdea marsupialis. Sheep red cells, but not human or rabbit red cells, were susceptible to lysis by the toxin. The toxin is a protein with an apparent molecular mass of about 102-107 kDa, is heat labile, highly unstable in polar media, inactivated by reducing agents, and devoid of phospholipase activity. The experimental data speak in favour of a pore-forming mechanism of toxin action.

引用

页码：315 / 326

页数：12

共 22 条

[11]

KARLSSON KA, 1991, SOURCEBOOK BACTERIAL, P435

[12] JELLYFISH DERMATITIS DUE TO CARYBDEA-MARSUPIALIS [J].