TRICYCLOHEXAPRENOL AND AN OCTAPRENEDIOL, 2 OF THE PRIMITIVE AMPHIPHILIC LIPIDS DO IMPROVE PHOSPHOLIPIDIC MEMBRANES

被引：17

作者：

KRAJEWSKIBERTRAND, MA

HAYER, M

WOLFF, G

MILON, A

ALBRECHT, AM

HEISSLER, D

NAKATANI, Y

OURISSON, G

机构：

[1] UNIV STRASBOURG 1,CTR NEUROCHIM,CHIM ORGAN SUBST NAT LAB,CNRS,URA 31,5 RUE BLAISE PASCAL,F-67084 STRASBOURG,FRANCE

[2] EHICS,PHYSICOCHIM BIOINORGAN LAB,CNRS,URA 405,F-67008 STRASBOURG,FRANCE

来源：

TETRAHEDRON | 1990年 / 46卷 / 09期

关键词：

membrane reinforcer; molecular evolution; octaprenediol; osmotic shock; tricyclohexaprenol;

D O I：

10.1016/S0040-4020(01)85454-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unilamellar vesicles were prepared from tricyclohexaprenol and dimyristoylphosphatidylcholine or a di-tertiary-octaprenediol and Halobacterium total polar lipids. Both tricyclohexaprenol and the octaprenediol were well incorporated in the membrane (up to 30mol% and 25mol% respectively). Effects of tricyclohexaprenol or the octaprenediol on the mechanical properties of the bilayer were investigated by the osmotic swelling method in a stopped-flow apparatus. These substances do not show a marked effect on the elasticity of the bilayer, but they do lower the water permeability through the membrane. Therefore, it was confirmed, at least in model systems, that these postulated phylogenetic precursors of cholesterol and carotenoids are membrane reinforcers. © 1990.

引用

页码：3143 / 3154

页数：12

共 18 条

[1] A DIRECT STUDY OF THE COHESION OF LECITHIN BILAYERS - THE EFFECT OF HOPANOIDS AND ALPHA,OMEGA-DIHYDROXYCAROTENOIDS [J].

BISSERET, P ;

WOLFF, G ;

ALBRECHT, AM ;

TANAKA, T ;

NAKATANI, Y ;

OURISSON, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 110 (01) :320-324

[2]

Cense J. -M., 1989, TETRAHEDRON COMPUTER, V2, P65, DOI 10.1016/0898-5529(89)90030-4

[3] SYNTHESIS OF 3 ACYCLIC ALL-TRANS-TETRATERPENE DIOLS, PUTATIVE PRECURSORS OF BACTERIAL LIPIDS [J].

CHAPPE, B ;

MUSIKAS, H ;

MARIE, D ;

OURISSON, G .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1988, 61 (01) :141-148

[4] MICRODETERMINATION OF PHOSPHORUS [J].

CHEN, PS ;

TORIBARA, TY ;

WARNER, H .

ANALYTICAL CHEMISTRY, 1956, 28 (11) :1756-1758

[5] TOTAL SYNTHESIS OF (+/-)-TRICYCLOHEXAPRENOL, A POSSIBLE FORERUNNER OF STEROLS IN THE EVOLUTION OF BIOMEMBRANES [J].

COREY, EJ ;

BURK, RM .

TETRAHEDRON LETTERS, 1987, 28 (51) :6413-6416

[6] SYNTHESIS OF (+)-TRICYCLOHEXAPRENOL, A POSSIBLE PRECURSOR OF A FAMILY OF TRICYCLIC GEOTERPANES, AND SYNTHESIS OF AN ISOMER [J].

HEISSLER, D ;

LADENBURGER, C .

TETRAHEDRON, 1988, 44 (09) :2513-2521

[7] PHYSICAL PRINCIPLES OF MEMBRANE ORGANIZATION [J].

ISRAELACHVILI, JN ;

MARCELJA, S ;

HORN, RG .

QUARTERLY REVIEWS OF BIOPHYSICS, 1980, 13 (02) :121-200

[8]

KATES M, 1982, METHOD ENZYMOL, V88, P98

[9] CHARACTERIZATION AND COMPOSITION OF PURPLE AND RED MEMBRANE FROM HALOBACTERIUM-CUTRIUBRUM [J].

KUSHWAHA, SC ;

KATES, M ;

MARTIN, WG .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1975, 53 (03) :284-292

[10] COMPARISON OF PURPLE MEMBRANE FROM HALOBACTERIUM-CUTIRUBRUM AND HALOBACTERIUM-HALOBIUM [J].

KUSHWAHA, SC ;

KATES, M ;

STOECKENIUS, W .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 426 (04) :703-710

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