COMPLEX KARYOTYPIC EVOLUTION IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA

被引：5

作者：

CROSSEN, PE ^{[1
]}

TULLY, SM ^{[1
]}

MORRISON, MJ ^{[1
]}

HEATON, DC ^{[1
]}

BENJES, SM ^{[1
]}

机构：

[1] CHRISTCHURCH HOSP,DEPT HEMATOL,CHRISTCHURCH,NEW ZEALAND

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 57卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0165-4608(91)90151-J

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis at diagnosis in a female patient with chronic B-cell leukemia showed a single abnormal clone with a 4p+ abnormality, 46,XX, -4, + der(4)t(4;?)(p16;?). Six additional clones evolved from this clone during the following 4 1/2 years and showed 3p+,4p-, and 11q- chromosomes in addition to the 4p+ abnormality. Immunoglobulin heavy chain gene rearrangement studies showed two rearranged bands and a faint germline band. Following splenectomy, a strong germline and faint rearranged bands were seen, suggesting that the majority of cells were normal, whereas cytogenetic studies showed that the karyotypically abnormal cells were still present. The combination of cytogenetic and Ig gene rearrangement studies provides detailed information regarding the number of circulating normal and leukemic cells.

引用

页码：187 / 194

页数：8

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