CIRCLING BEHAVIOR INDUCED BY ACTIVATION OF GABA(A) RECEPTORS IN THE SUBTHALAMIC NUCLEUS

被引：39

作者：

MURER, MG ^{[1
]}

PAZO, JH ^{[1
]}

机构：

[1] UNIV BUENOS AIRES, FAC MED,DEPT FISIOL,NEUROFISIOL LAB,PARAGUAY 2155, RA-1121 BUENOS AIRES, ARGENTINA

来源：

NEUROREPORT | 1993年 / 4卷 / 11期

关键词：

SUBTHALAMIC NUCLEUS; GABA(A) RECEPTORS; CIRCLING BEHAVIOR; ZONA INCERTA; FIELDS OF FOREL; TORTICOLIS; ENTOPEDUNCULAR NUCLEUS; CATS;

D O I：

10.1097/00001756-199309000-00002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE behavioural effect of drugs acting on GABA(A) receptors in the subthalamic region and the entopeduncular nucleus was studied in freely moving cats. Microinjections of muscimol into the zona incerta-Forel's fields produced tilt of the head to the injected site, while injections of bicuculline or picrotoxin produced the same effect but to the opposite side. Microinjections of muscimol into the subthalamic nucleus elicited circling behaviour to the contralateral side, while bicuculline and picrotoxin produced ipsilateral turning. However, when high doses of the antagonists were injected, contralateral circling was observed. Activation or blockade of GABA(A) receptors into the entopeduncular nucleus was ineffective. These results imply that GABAergic mechanisms in the subthalamic nucleus and the zona incerta-fields of Forel are involved in circling behaviour and vertical head movements, respectively.

引用

页码：1219 / 1222

页数：4

共 24 条

[1] FELINE SUBTHALAMIC NUCLEUS NEURONS CONTAIN GLUTAMATE-LIKE BUT NOT GABA-LIKE OR GLYCINE-LIKE IMMUNOREACTIVITY [J].