EPIDEMIC SPREAD AND ANTIGENIC VARIABILITY OF NEISSERIA-MENINGITIDIS

被引：61

作者：

ACHTMAN, M ^{[1
]}

机构：

[1] MAX PLANCK INST MOLEC GENET,D-14195 BERLIN,GERMANY

来源：

TRENDS IN MICROBIOLOGY | 1995年 / 3卷 / 05期

关键词：

D O I：

10.1016/S0966-842X(00)88918-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Genetic variation of cell-surface antigens of serogroup A meningococci arises from horizontal genetic exchange. Most clonal variants are lost by clonal reduction during epidemic and pandemic spread, but in exceptional cases, genetic variants are rapidly fixed in the bacterial population by clonal replacement.

引用

页码：186 / 192

页数：7

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