Liquid chromatography coupled with time-of-flight and ion trap mass spectrometry for qualitative analysis of herbal medicines

被引：37

作者：

Chen, Xiao-Fei ^{[1
,2
]}

Wu, Hai-Tang ^{[1
,2
]}

Tan, Guang-Guo ^{[1
,2
]}

Zhu, Zhen-Yu ^{[1
,2
]}

Chai, Yi-Feng ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmaceut Anal, Shanghai 200433, Peoples R China

[2] Shanghai Key Lab Pharmaceut Metabolite Res, Shanghai 200433, Peoples R China

来源：

JOURNAL OF PHARMACEUTICAL ANALYSIS | 2011年 / 1卷 / 04期

关键词：

High-performance liquid chromatography (HPLC); Time-of-flight mass spectrometry (TOF-MS); Ion trap mass spectrometry (IT-MS); Herbal medicine (HM);

D O I：

10.1016/j.jpha.2011.09.008

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

With the expansion of herbal medicine (HM) market, the issue on how to apply up-todate analytical tools on qualitative analysis of HMs to assure their quality, safety and efficacy has been arousing great attention. Due to its inherent characteristics of accurate mass measurements and multiple stages analysis, the integrated strategy of liquid chromatography (LC) coupled with time-of-flight mass spectrometry (TOF-MS) and ion trap mass spectrometry (IT-MS) is well-suited to be performed as qualitative analysis tool in this field. The purpose of this review is to provide an overview on the potential of this integrated strategy, including the review of general features of LC-IT-MS and LC-TOF-MS, the advantages of their combination, the common procedures for structure elucidation, the potential of LC-hybrid-IT-TOF/MS and also the summary and discussion of the applications of the integrated strategy for HM qualitative analysis (2006-2011). The advantages and future developments of LC coupled with IT and TOF-MS are highlighted.(C) 2011 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：235 / 245

页数：11

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