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THE ENZYMATIC AND CHEMICAL-REDUCTION OF EXTENDED BILIVERDINS

被引：9
作者：
FRYDMAN, RB
BARI, S
TOMARO, ML
FRYDMAN, B
机构：
[1] Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires Junín
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 171卷 / 01期
关键词：
D O I：
10.1016/0006-291X(90)91416-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The substrate specificity of rat liver biliverdin reductase was probed using helical and extended biliverdins. The former were the ZZZ-all-syn biliverdins IX α and IX γ, and the latter were the 5Z-syn, 10Z-syn, 15z-anti; 5Z-anti, 10Z-syn, 15Z-anti; 5Z-syn, 10E-anti, 15Z-syn; 5Z-syn, 10E-anti, 15Z-anti and 5Z-anti, 10E-anti, 15E-anti biliverdins. It was found that the reduction rates of the biliverdins increased with the progressive stretching of their conformations. The most extended biliverdin was reduced at a higher rate than biliverdin IX α. The chemical reduction rates to bilirubins followed a similar pattern. Nuceophilic ad dition of 2-mercaptoethanol to the C10 methine was also favored in the extended biliverdins. © 1990.
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页码：465 / 473
页数：9
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