NACL INDUCES DIFFERENTIAL CHANGES OF REGIONAL VASCULAR REACTIVITY IN SALT-SENSITIVE VERSUS SALT-RESISTANT MEN

被引：15

作者：

EGAN, BM

PETRIN, J

HOFFMANN, RG

机构：

[1] Department of Medicine Division of Cardiology and Department of Biostatistics, Medical College of Wisconsin, Milwaukee

[2] Department of Medicine, Division of Hypertension, University of Michigan, Ann Arbor, MI

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 12期

关键词：

BLOOD PRESSURE; SALT; VASCULAR RESISTANCE; NOREPINEPHRINE ANGIOTENSIN-II; NITROPRUSSIDE; VERAPAMIL; PHENTOLAMINE;

D O I：

10.1093/ajh/4.12.924

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The objective of our study was to determine the structural or functional factors which increase forearm vascular resistance (FAVR) during a high NaCl diet in salt-sensitive (SS) volunteers. We studied the effects of 20 v 200 mEq/day NaCl diets on FAVR responses to norepinephrine (NE), angiotensin II (AII), nitroprusside, verapamil, and ischemia in 27 men. Twelve men had supine mean arterial pressure (MAP) on high NaCl which was greater-than-or-equal-to 5% above MAP on low NaCl and were consequently labeled SS. Eleven subjects had lower MAP on the high NaCl diet and were classified salt-resistant (SR). Basal FAVR was greater in SS (P < .005) and unchanged in SR subjects on high (v low) NaCl. FAVR responses to NE and nitroprusside were not different between the two diets within either the SS or SR subgroups. FAVR responses to AII decreased during high NaCl in the SR (P < .01), but not in the SS subset. The response to phentolamine and verapamil increased in SS (P less-than-or-equal-to .05) and tended to decrease in SR subjects (P < .15) during high NaCl. In contrast, the vasodilator response to ischemia was impaired in the SS (P = .02) and enhanced in the SR (P = .02) group on high v low NaCl. Enhanced alpha-adrenergic and Ca2+ channel (verapamil)-dependent vascular tone probably contribute to the greater baseline FAVR in SS subjects on high NaCl. Failure to decrease vasoconstrictor responses to AII may indirectly contribute to their maladjustment of FAVR. While greater post-ischemic FAVR in SS subjects on high NaCl suggests structural changes, vascular reactivity is selectively and not globally altered. Thus, increased baseline and postischemic FAVR in SS subjects after 1 week on high NaCl is probably explained more by functional than by structural changes.

引用

页码：924 / 931

页数：8

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