ACTIVATION OF PC12 CELLS BY LIPOPHILIC COMPONENTS OF PANAX-GINSENG

被引：16

作者：

MOHRI, T ^{[1
]}

CHIBA, K ^{[1
]}

YAMAZAKI, M ^{[1
]}

SHIMIZU, M ^{[1
]}

MORITA, N ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV,FAC PHARMACEUT SCI,SUGITANI,TOYAMA 93001,JAPAN

来源：

PLANTA MEDICA | 1992年 / 58卷 / 04期

关键词：

PANAX-GINSENG; LIPOPHILIC COMPONENTS; PC12; CELLS; NEURITE OUTGROWTH; ACETYLCHOLINE RECEPTOR;

D O I：

10.1055/s-2006-961476

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The lipid soluble fraction of Panax ginseng C. A. Meyer has been found to possess a stimulatory effect on a para-neuronal culture cell line, namely PC12 cells. Addition of the diethyl ether extract (0.025-0.1 mg/ml) of Ginseng radix to a culture medium promoted the outgrowth of neurites from cells dose-dependently as well as their ready differentiation to respond to carbachol and high KCl-evoked membrane depolarization to induce free Ca2+ accumulation in the cells within a week of culture. Effective constituents of the extract were confined to four major substances detected in the extremely lipophilic front area on silica gel TLC.

引用

页码：321 / 323

页数：3

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