THE EFFECT OF GAMMA-RADIATION ON THE TABLETING PROPERTIES OF SOME PHARMACEUTICAL EXCIPIENTS

被引：3

作者：

ELBAGORY, I

REID, BD

MITCHELL, AG

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,2146 E MALL,VANCOUVER V6T 1Z3,BC,CANADA

[2] NORDION INT INC,KANATA K2K 1X8,ON,CANADA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 105卷 / 03期

关键词：

RADIATION; TABLETING EXCIPIENT; TABLETING PARAMETERS;

D O I：

10.1016/0378-5173(94)90110-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gamma radiation should provide an acceptable method for the sterilization of tableting excipients provided there are no deleterious effects on tableting properties. Three direct compression excipients and maize starch were exposed to gamma radiation at doses of 0, 5, 10 and 25 kGy. Tablets were compressed on an instrumented rotary press. No measurable differences were found between the tableting properties of the irradiated and non-irradiated materials. The effectiveness of maize starch as a disintegrant was not affected by radiation.

引用

页码：255 / 258

页数：4

共 10 条

[1] PEAK OFFSET TIMES AS AN INDICATION OF STRESS-RELAXATION DURING TABLETTING ON A ROTARY TABLET PRESS [J].