PROGESTERONE AND RU486 - OPPOSING EFFECTS ON HUMAN SPERM

被引：97

作者：

YANG, J

SERRES, C

PHILIBERT, D

ROBEL, P

BAULIEU, EE

JOUANNET, P

机构：

[1] INSERM,U33,F-94276 LE KREMLIN BICETR,FRANCE

[2] UNIV PARIS SUD,FAC MED,HISTOL EMBRYOL CYTOGENET LAB,F-94270 LE KREMLIN BICETR,FRANCE

[3] UCLAF,CTR RECH ROUSSEL,F-92230 ROMAINVILLE,FRANCE

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 02期

关键词：

CAPACITATION; HYPERACTIVATION; ACROSOME REACTION; INTRACELLULAR CALCIUM CONCENTRATION;

D O I：

10.1073/pnas.91.2.529

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Progesterone induced a rapid influx of calcium in capacitated human sperm, followed by a long-lasting, dose-dependent increase of intracellular free calcium. Thereafter, progesterone increased the fraction of hyperactivated sperm and the acrosome reaction. On the contrary, the progesterone antagonist RU486 (mifepristone) induced an immediate and transient, dose-dependent decrease of intracellular free calcium and a drop in the values of sperm movement parameters related to hyperactivation. Moreover, RU486 counteracted the effects of progesterone on calcium influx, lateral sperm head displacement, and the acrosome reaction. Therefore, RU486 effects were opposite to those of progester-one one, The nature of the membrane receptor(s) involved is unknown. Several steroids bearing 11 beta-phenyl substitutions, with different pharmacological profiles, were also investigated. It was concluded that the steroid structure and chemical groups added to the 11 beta-phenyl influence effects on calcium influx.

引用

页码：529 / 533

页数：5

共 30 条

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